放射治疗对肺癌患者TNF-α及INF-γ的影响  

The Effect of radiotherapy on IFN-r and TNF-a of Lung Cancer Patients

作　　者：白璐[1] 刘承一[1] 张晶晶[1] 高东奇[1] 李文鑫 孙宝信[1] BAI Lu;LIU Chengyi;ZHANG Jingjing(The Affiliated hospital of Chengde Mediacal collage,Chengde Hebei 067000,China)

机构地区：[1]承德医学院附属医院肿瘤科

出　　处：《河北医学》2019年第9期1474-1476,共3页Hebei Medicine

基　　金：承德市科技计划支撑项目,项目编号:201701A036

摘　　要：目的:探讨接受放射治疗的肺癌患者放疗前及不同放射剂量时外周血中TNF-α及INF-γ的变化。方法:对该科收治的30例肺癌放疗患者在放射治疗前、放射治疗2周、4周、6周分别通过ELISA检测外周血中IFN-r、TNF-a的含量。结果:IFN-r的浓度于放疗2000cGy、4000cGy、6000cGy时逐渐升高,F=961.32,P<0.001;TNF-a于放疗2000cGy、4000cGy、6000cGy时逐渐下降,F值为734.85,P值P<0.001。结论:放疗可提高肺癌患者血清中INF-r的水平,降低TNF-a的水平。Objective:Discuss the dynamic changes of TNF-αand INF-γin peripherd blood of patients with lung cancer before and after different dose radiotherapy.Methods:To detect the content of IFN-r、TNF-a in Peripheral blood of 30 lung cancer radiotherapy patients by ELISA before radiotherapy 1 weeks after radiotherapy,2 weeks,4 weeks and 6 weeks.Results:The concentration of IFN-r increased gradually at 2 000cGy,4000cGy and 6000cGy by radiotherapy.F=961.32,P<0.001.The concentration of TNF-a decreased gradually at 2 000cGy,4000cGy and 6000cGy by radiotherapy.The F values were 734.85,respectively,and P values were P<0.001.Conclusion:Radiotherapy can enhance the level of INF-r with lung cancer patients,and reduce the level of TNF-a.

关 键 词：肺癌 放疗 肿瘤坏死因子-Α 干扰素-Γ 

分 类 号：R73[医药卫生—肿瘤]