铁基纳米药物的研究现状与发展趋势  

Research status and development trend of iron-based nano-medicine

作　　者：陈博 孙剑飞 韩樾夏 顾宁 Bo Chen;Jianfei Sun;Yuexia Han;Ning Gu(Institute of Material Science and Devices,Suzhou University of Science and Technology,Suzhou 215009,China;Jiangsu Key Laboratory for Biomaterials and Devices,State Key Laboratory of Bioelectronics,School of Biological Science&Medical Engineering,Southeast University,Nanjing 210096,China)

机构地区：[1]苏州科技大学材料科学与器件研究院,苏州215009 [2]东南大学生物科学与医学工程学院,江苏省生物材料与器件重点实验室,生物电子学国家重点实验室,南京210096

出　　处：《中国科学：化学》2019年第9期1156-1167,共12页SCIENTIA SINICA Chimica

基　　金：国家重点研发计划(编号:2017YFA0104301);国家自然科学基金(编号:51832001,21705115)资助项目

摘　　要：铁基纳米药物是目前屈指可数的临床用无机金属纳米材料,已成功用于磁共振影像增强、静脉补铁及磁致热疗等医疗领域.由于该类药物特殊的纳米属性与磁学功能,随着现代生物医学研究的不断深入,铁基纳米药物的生产工艺及质量标准需要更为严格和系统地制定.测试技术,尤其是对铁基组分的分析检测方法,需要革新并建立该类产品的质量控制体系.与此同时,新型铁基纳米药物的研发以及多项针对新适应症的临床试验也在积极进行中.本文总结了铁基纳米药物的分类、用途、主要制备技术及产品标准的研究现状,展望了新型铁基纳米药物的发展趋势.Iron-based nano-medicine(IBN), as one of the few inorganic metal nano-medicines that currently have been approved for clinical applications, has become available to use in areas such as MRI contrast agent, intravenous iron supplementation, and magnetically-induced hyperthermia. Given its distinctive nano-performance and magnetic property, coupled by the ever-evolving research in modern biology medicine, it calls for more rigorous and systemic research on the preparation process and standard of quality;an increasing need of innovating the testing mechanism with specific regard to the analysis and detection method of iron-based components;and a pressing need to establish the quality control system accordingly. Meantime, the novel iron-based nano-medicine is also developing fast and a number of clinical trials, specifically targeted at new usages, are under active development. This review summarizes iron-based nano-medicine in regard to its existing classification, applications, primary preparation techniques, and product standards and forecasts its development trend based on the research status of new IBN in clinical translation.

关 键 词：铁基 纳米药物 药品标准 临床转化 发展前景 

分 类 号：TB3[一般工业技术—材料科学与工程]