270例脑胶质瘤患者术后精确放疗的临床观察  

Clinical observation of postoperative precise radiotherapy for 270 patients with glioma

作　　者：黄仁华[1] 徐欣[1] 吴峥 周荻[1] 谢华英[1] 叶明[1] 马秀梅[1] 白永瑞[1] HUANG Renhua;XU Xin;WU Zheng;ZHOU Di;XIE Huaying;YE Ming;MA Xiumei;BAI Yongrui(Department of Radiotherapy,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院放疗科

出　　处：《临床肿瘤学杂志》2019年第9期819-823,共5页Chinese Clinical Oncology

摘　　要：目的探讨脑胶质瘤术后精确放疗及预后的影响因素。方法收集2005年7月至2014年5月收治的270例脑胶质瘤术后精确放疗患者,单因素和多因素分析年龄、性别、KPS、肿瘤部位、放疗手术时间、病理分级、手术方式及是否术后同步放化疗等对脑胶质瘤患者术后放疗总生存时间(OS)的影响。结果全组患者的1年生存率79%,2年生存率55%,3年生存率46%,OS为30个月。单因素分析显示KPS评分(P=0.012),病理分级(P<0.001)及手术切除程度(P<0.001)影响胶质瘤患者术后OS的因素。Cox风险比例回归分析显示KPS(P=0.002)、病理分级(P<0.001)、手术切除程度(P<0.001)及同步化疗是影响患者的独立预后因素。结论患者一般状况好、病理低级别、手术切除程度高有益于胶质瘤患者术后精确放疗获益。Objective To explore the factors influencing the precise radiotherapy and prognosis of glioma after operation.Methods From July 2005 to May 2014,270 patients with glioma received precise radiotherapy after operation were collected.The effects of age,sex,KPS,tumor location,time of radiotherapy,pathological grade,operation mode and whether or not concurrent radiotherapy and chemotherapy were analyzed by univariate and multivariate analysis.Results The 1-year survival rate was 79%,the 2-year survival rate was 55%,the 3-year survival rate was 46%,and the OS was 30 months.Univariate analysis showed that KPS score(P=0.012),pathological grade(P<0.001)and degree of surgical excision(P<0.001)affected the OS of glioma patients after surgery.Cox proportional regression analysis showed that KPS(P=0.002),pathological grade(P<0.001),degree of surgical excision(P<0.001)and concurrent chemotherapy were independent prognostic factors.Conclusion Good general condition,low pathological grade and high degree of surgical excision are beneficial to precise radiotherapy for glioma patients.

关 键 词：脑胶质瘤 精确放射治疗 预后因素 

分 类 号：R739.41[医药卫生—肿瘤]