成年偏头痛并发广泛性焦虑障碍治疗前后胼胝体磁共振弥散张量成像分析  

Analysis on MR Diffusion Tensor Imaging of Corpus Callosum in Adult Migraine Complicated with Generalized Anxiety Disorder before and after Treatment

作　　者：李现亮[1] 李学龙 黎少君 魏佳娜 傅贤[1] 潘英[1] 高庆春[1] LI Xianliang;LI Xuelong;LI Shaojun;WEI Jia’na;FU Xian;PAN Ying;GAO Qingchun(Department of Neurology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院神经内科

出　　处：《临床医学工程》2019年第9期1161-1162,共2页Clinical Medicine & Engineering

基　　金：广东省医学科学技术研究基金项目(项目编号:A2016048)

摘　　要：目的研究成年偏头痛并发广泛性焦虑障碍患者胼胝体可能存在的微细结构异常,探讨其治疗前后的变化特点。方法选择28例成年偏头痛并发广泛性焦虑障碍患者(患者组)及28名健康体检者(对照组)进行磁共振弥散张量成像检查,分别于胼胝体膝部、体部及压部设置感兴趣区,测取部分各向异性值(FA)和表观弥散系数值(ADC)。结果治疗前,患者组胼胝体膝部及体部FA值均明显低于对照组(P<0.01)。治疗后,患者组胼胝体膝部及体部FA值均较治疗前明显升高(P<0.01)。患者组HAM-A评分与胼胝体膝部FA值在治疗前后均呈负相关(P<0.05)。结论成年偏头痛并发广泛性焦虑障碍患者存在胼胝体神经纤维微细结构完整性的损害,经有效治疗这种损害是可逆的。Objective To study the possible microstructural abnormalities of the corpus callosum(CC)in adult migraine complicated with generalized anxiety disorder(GAD)before and after treatment.Methods 28 cases of adult patients with migraine and GAD(patient group)and 28 healthy physical examiner(control group)were given MR diffusion tensor imaging.Fractional anisotropy(FA)and apparent diffusion coefficient(ADC)were measured at CC genu,body and splenium respectively.Results Before treatment,the FA values at CC genu and body of the patient group were significantly lower than those of the control group(P<0.01).After treatment,the FA values at CC genu and body of the patient group were significantly higher than those before treatment(P<0.01).There were negative correlations between HAM-A scores and FA values at CC genu before and after treatment in patient group(P<0.05).Conclusions Adult patients with migraine complicated with GAD have integrity damage of CC neurofibrotic microstructures,which may be reversible through effective treatment.

关 键 词：偏头痛 广泛性焦虑障碍 胼胝体 磁共振弥散张量成像 

分 类 号：R747.2[医药卫生—神经病学与精神病学]