Role of CD20^+ T cells in multiple sclerosis:implications for treatment with ocrelizumab  

作　　者：Stefan Gingele Thomas Skripuletz Roland Jacobs 

机构地区：[1]Department of Neurology,Hannover Medical School,Hannover,Germany [2]Department of Clinical Immunology&Rheumatology,Hannover Medical School,Hannover,Germany

出　　处：《Neural Regeneration Research》2020年第4期663-664,共2页中国神经再生研究（英文版）

摘　　要：Features of CD20^+T cells:CD20 is a membrane-spanning hosphoprotein strongly expressed on the cell surface of B lineage cells and is widely regarded as a B cell specific marker.However,CD20(Figure 1)is also expressed at a low level on a small subset of CD3^+T cells which therefore are sometimes referred to as CD20dimCD3^+T cells in contrast to CD20brightCD19^+B cells which represent the majority of cells expressing CD20(Hultin et al.,1993).The amount of the CD20 antigen has been assessed to be 25 to 50 times higher on CD20^+CD19^+B cells compared to CD20^+CD3^+T cells(Hultin et al.,1993).At first description of this cell population the frequency of these CD20^+T cells has been described to represent an average of 2.4%of all peripheral blood lymphocytes(50 healthy controls)(Hultin et al.,1993).

关 键 词：al. CD20 assessed 

分 类 号：R73[医药卫生—肿瘤]