埃博拉病毒包膜糖蛋白变异及抗原表位研究进展  

Research Progress in the Envelope Glycoprotein Variation and Epitope of Ebola Virus

作　　者：刘硕 张黎[2] 王玉琳[1] 黄维金[2] 王佑春[2] LIU Shuo;ZHANG Li;WANG Yulin;HUANG Weijin;WANG Youchun(National Vaccine Serum Institute of China,Sinopharm Zhongsheng Biotechnology Research Institute Company Limited,Beijing 101111,China;National Institutes for Food and Drug Control,Key Laboratory of Calibration Methods and Standardization of BiotechnologyProducts o fthe Ministry of Health,Beijing 102629,China)

机构地区：[1]北京生物制品研究所,国药中生生物技术研究院有限公司,北京101111 [2]中国食品药品检定研究院,卫生部生物技术产品检定方法与标准化重点实验室,北京102629

出　　处：《病毒学报》2019年第5期801-812,共12页Chinese Journal of Virology

基　　金：艾滋病和病毒性肝炎等重大传染病防治专项(项目号:2017ZX10304402),题目:新发突发重大传染病动物模型的构建及标准化~~

摘　　要：埃博拉病毒在人类和非人灵长类中引起严重出血热疾病,死亡率高。包膜糖蛋白为埃博拉病毒唯一与病毒吸附宿主细胞、融合和进入等功能相关的蛋白。包膜糖蛋白突变会影响病毒感染力、细胞嗜性和与抗血清的中和敏感性。本文系统分析了埃博拉病毒包膜糖蛋白的氨基酸突变,结合抗体结合位点和T细胞表位分析其对于埃博拉病毒感染和疫苗保护效果的影响。Ebola virus causes severe hemorrhagic fever in human and non-human primates with high mortality.The envelope glycoprotein is the only protein associated with the function of the virus binding to host cells,fusion and entry. Mutations in the envelope glycoprotein affect viral infectivity,cell-type tropism,and sensitivity to neutralizing antisera. This paper systematically analyzed the amino acid mutations of Ebola virus envelope glycoprotein,and combined with antibody binding site and T cell epitope to analyze its effect on Ebola virus infection and vaccine protection.

关 键 词：出血热 埃博拉病毒 抗原表位 基因突变 

分 类 号：R373.9[医药卫生—病原生物学] R511[医药卫生—基础医学]