15例下颌下腺复发性多形性腺瘤临床病理分析  

Recurrent pleomorphic adenoma of the submandibular gland:a clinical and pathologic study of 15 cases

作　　者：徐万林 朱云[1] 卢浩 刘丽敏[2] 沈淑坤[1] 刘胜文[1] 杨雯君[1] XU Wan-lin;ZHU Yun;LU Hao;LIU Li-min;SHEN Shu-kun;LIU Sheng-wen;YANG Wen-jun(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China;Department of Oral Pathology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011 [2]上海交通大学医学院附属第九人民医院·口腔医学院口腔病理科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011

出　　处：《中国口腔颌面外科杂志》2019年第5期465-468,共4页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金青年项目(81302359);上海市科学技术委员会研究基金(16ZR1418800)

摘　　要：目的:观察下颌下腺复发性多形性腺瘤的临床和组织病理学特征,探讨其病因与治疗。方法:回顾分析2005年6月—2017年6月我院诊治的15例下颌下腺复发性多形性腺瘤患者的临床和病理资料。结果:15例患者中,男4例(26.67%),女11例(73.33%);年龄25~73岁,平均年龄39.33岁;3例(20%)复发2次,其余12例(80%)复发1次,平均复发间期是16.3 a。所有患者均采用肿物及下颌下腺切除术(除2例前次手术已切除下颌下腺者外),术后病理均证实为复发性多形性腺瘤,多结节生长且大多包膜不完整。随访1~13 a,中位随访时间6 a,仅1例(6.67%)患者可疑复发,因其年龄较大,无手术意愿而未行再次手术治疗。结论:下颌下腺复发性多形性腺瘤尚不多见,其临床病理特征与原发性多形性腺瘤类似,手术是有效的治疗方式。PURPOSE:To investigate the clinicopathological feature of recurrent pleomorphic adenoma of the submandibular gland,and discuss its diagnosis,treatment and prognosis.METHODS:From June 2005 to June 2017,the clinical data and pathological features of 15 cases of recurrent pleomorphic adenoma of the submandibular gland treated in Shanghai Ninth People's Hospital were reviewed and analyzed retrospectively.RESULTS:Among 15 cases,4(26.67%)were male while 11(73.33%)were female.Their age ranged from 25 to 73 years old(mean:39.33).Three cases(20%)recurred twice and the other 12 patients(80%)recurred once.All patients underwent excision of the mass and submandibular gland(except 2 cases who had undergone excision of the submandibular gland in previous surgery),and the pathological results were recurrent pleomorphic adenoma,with multi-nodules and incomplete capsule.The follow-up period was 1-13 years(median:6)and only 1 patient(6.67%)suffered from suspected recurrence,who didn't receive second surgery due to his old age.CONCLUSIONS:Recurrent pleomorphic adenoma in the submandibular gland is rare.Its clinical and pathological features were similar to those of the primary pleomorphic adenoma and surgical treatment is effective.

关 键 词：多形性腺瘤 下颌下腺 唾液腺 复发 

分 类 号：R739.8[医药卫生—肿瘤]