糖尿病合并华氏巨球蛋白血症一例报告  

Coexistence of diabetes mellitus and Waldenstrom macroglobulinebia: One case report

作　　者：陈方圆 吴跃跃 黄新梅 于志艳 张瑞 王芳 孙田歌 丁和远 刘军 Chen Fangyuan;Wu Yueyue;Huang Xinmei;Yu Zhiyan;Zhang Rui;Wang Fang;Sun Tiange;Ding Heyuan;Liu Jun(Department of Endocrinology,Shanghai Fifth People′s Hospital Affiliated to Fudan University,Shanghai 200240,China)

机构地区：[1]复旦大学附属上海市第五人民医院内分泌代谢科,上海200240

出　　处：《中华内分泌代谢杂志》2019年第9期789-791,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市"科技创新行动计划"自然科学基金项目(19ZR1440200)。

摘　　要：本文报道1例患有糖尿病20余年的男性患者,因乏力、纳差、血糖明显升高就诊。起初考虑糖尿病血糖控制不佳,以及已经存在糖尿病相关并发症可能;入院常规检查提示球蛋白升高,免疫功能检查提示以免疫球蛋白M(IgM)升高为主,后续影像学检查提示存在双侧少量胸腔积液,且经过降糖治疗2周后,血糖明显好转,但症状仍然存在,结合患者实验室检查结果,考虑合并血液系统疾病,请血液科会诊;经进一步完善免疫电泳、骨髓细胞学、流式细胞学等检查,确诊为华氏巨球蛋白血症,予硼替佐米+地塞米松方案化疗。患者目前化疗1个疗程,乏力纳差症状明显好转。糖尿病合并华氏巨球蛋白血症临床非常罕见,极易误诊为糖尿病的并发症,两者均可表现为纳差、乏力,以及周围神经病变等症状。当糖尿病患者存在异常免疫球蛋白增高,以及其他不能用糖尿病很好解释的异常检查结果时,应考虑其他潜在疾患,比如血液系统疾病,以避免漏诊。This paper reports a case of a male patient with diabetes for more than 20 years who came to see doctor due to weakness, poor appetite and significantly elevated blood glucose. At first, it was considered that the poor blood glucose control of diabetes was the reason, and the possibility of diabetes related complications already existed. Hospital routine examination indicated a globulin increase and immunologic examination indicated that IgM was mainly increased. Subsequent imageological diagnosis revealed a small amount of bilateral pleural effusion, and after 2 weeks of hypoglycemic treatment, the blood glucose was significantly improved, but the symptoms still existed. In combination with the patient′s laboratory examination, considering the combination of blood system diseases, the hematology department was invited for consultation. Immunoelectrophoresis, bone marrow cytology, and flow cytometry were further conducted, and the patient was diagnosed with Waldenstrom macroglobulinebia. Bortezomib + dexamethasone regimen was given for chemotherapy. Currently, the patient has received 1 course of chemotherapy, and the symptoms of poor appetite were significantly improved. Coexistence of diabetes mellitus and Waldenstrom macroglobulinebia is very rare in clinical practice, and it is easy to be misdiagnosed as a complication of diabetes mellitus, both of which can be manifested as poor appetite, weakness, peripheral neuropathy and other symptoms. When diabetic patients have abnormal immunoglobulin increases and other abnormal test results that cannot be well explained by diabetes, other potential disorders, such as hematological diseases, should be considered to avoid missed diagnosis.

关 键 词：糖尿病 华氏巨球蛋白血症 免疫球蛋白 

分 类 号：R73[医药卫生—肿瘤]