血清内sB7-H3与IL-1对乙肝相关肝癌患者的临床意义  

Clinical significance of serum sB7-H3 and IL-1 in patients with hepatitis B related hepatocellular carcinoma

作　　者：戴锋[1] 付守忠[1] 王斌[1] 丁苇[1] 王晓维[1] 沈建东[1] 殷梦杰 DAI Feng;FU Shou-zhong;WANG Bin;DING Wei;WANG Xiao-wei;SHEN Jian-dong;YIN Meng-jie(Intervention Department of Nantong Third People's Hospital,Nantong 226000,China)

机构地区：[1]南通市第三人民医院介入科

出　　处：《海南医学院学报》2019年第19期1496-1500,1506,共6页Journal of Hainan Medical University

基　　金：2018年南通市市级科技计划(指导性)项目(MSZ18183)~~

摘　　要：目的:探讨血清内可溶性B7-H3(sB7-H3)与白介素-1(IL-1)对乙肝相关肝癌患者的临床意义。方法:选取于我院收治的122例乙肝相关肝病患者为研究对象,包括47例乙肝相关肝癌患者、41例乙肝相关肝硬化患者、34例乙型肝炎患者,选取同期45例健康体检者作为健康对照组。比较各组血清内sB7-H3、白介素-1α(IL-1α)、白介素-1β(IL-1β)水平,分析乙肝相关肝癌患者血清内sB7-H3、IL-1α、IL-1β水平与临床病理特征的关系。采用Pearson法分析sB7-H3、IL-1α、IL-1β水平的相关性,采用ROC、Logistic回归分析血清内sB7-H3、IL-1α、IL-1β水平对乙肝相关肝癌早期诊断及预后评估的效能。结果:各组受试者血清内sB7-H3、IL-1α、IL-1β水平从高至低依次为:乙肝相关肝癌组>乙肝相关肝硬化组>乙肝组患者>健康对照组,差异均具有统计学意义(P<0.05)。血清内sB7-H3、IL-1α、IL-1β水平与乙肝相关肝癌患者的肿瘤TNM分期、甲胎蛋白水平及远处转移情况显著相关(P<0.05)。Pearson相关性分析结果显示,血清内sB7-H3水平与IL-1α、IL-1β水平均呈正相关(r=0.837、0.756,P<0.05),IL-1α与IL-1β水平呈正相关(r=0.734,P<0.05)。ROC和Logistic回归分析结果显示,sB7-H3、IL-1α、IL-1β及三者联合检测诊断乙肝相关肝癌的AUC分别为0.893、0.887、0.881、0.961(P<0.05),评估其预后的AUC分别为0.843、0.837、0.834、0.917(P<0.05)。结论:血清内sB7-H3、IL-1α、IL-1β水平均可用于乙肝相关肝癌患者的早期诊断及预后评估,三者联合检测效果更佳,具有重要的临床意义。Objective:To explore the clinical significance of serum sB7-H3 and IL-1 in patients with hepatitis B associated hepatocellular carcinoma.Methods:In total of 122 cases of patients with hepatitis B related liver diseases admitted to our hospital from January 2015 to June 2018 were selected,including 47 cases of patients with hepatitis B related hepatocellular carcinoma,41 cases of patients with hepatitis B related cirrhosis and 34 cases of patients with hepatitis B virus,and 45 cases of healthy persons in the same period as the normal control group.The serum sB7-H3,IL-1α,IL-1βlevels were compared among the four groups.The relationship between serum sB7-H3,IL-1α,IL-1βand clinicopathological characteristics was analyzed,and the correlation of sB7-H3,IL-1αand IL-1βwas analyzed by Pearson method.The efficacy of serum sB7-H3,IL-1α,IL-1βin early diagnosis and prognostic evaluation for hepatitis B associated hepatocellular carcinoma were analyzed by ROC and Logistic regression analysis.Results:The serum sB7-H3,IL-1α,IL-1βlevels in the four groups were in order from high to low:hepatitis B related hepatocellular carcinoma>hepatitis B related cirrhosis>hepatitis B virus>the normal control group,all above had statistical difference(P<0.05).The high levels of serum sB7-H3,IL-1α,IL-1βwere significantly correlated with TNM stage,alpha fetoprotein level and lymph node metastasis(P<0.05).Spearman correlation analysis results showed that the serum level of sB7-H3 was positively correlated with IL-1αand IL-1β(r=0.837,0.756;P<0.05),the serum level of IL-1αwas positively correlated with IL-1β(r=0.734,P<0.05).The ROC curve and logistic regression analysis showed that the AUC of sB7-H3,IL-1α,IL-1βand combined detection for the diagnosis of hepatitis B associated hepatocellular carcinoma was 0.893,0.887,0.881,0.961(P<0.05),respectively;the AUC of sB7-H3,IL-1α,IL-1βand combined detection for the prognostic evaluation for hepatitis B associated hepatocellular carcinoma was 0.843,0.837,0.834,0.917,respectively.Conclusio

关 键 词：乙肝相关肝癌 sB7-H3 IL-1 诊断 预后评估 

分 类 号：R735.7[医药卫生—肿瘤] R512.62[医药卫生—临床医学]