MEDICAL ENGINEERING COOPERATIVE STUDY OF EVENT-RELATED BRAIN POTENTIAL N400 IN PATIENTS WITH BIPOLAR DEPRESSION  

作　　者：Zhang Li Xu Chuchen Shen Hui Chen Meijuan Zhang Yi Lin Xiaodong Chen Ce Dai Bojian 

机构地区：[1]Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China [2]Department of Psychiatry,Wenzhou Seventh People’s Hospital,Wenzhou 325005,China

出　　处：《现代电生理学杂志》2019年第B03期12-18,共7页Journal of Modern Electrophysiology

摘　　要：Objective:To explore the difference and its clinical significance of event-related potential N400 in patients with bipolar depression,unipolar depression and schizophrenia Methods:It was N400 detection for 24 cases of bipolar depression,25 cases of unipolar depression,26 cases of schizophrenia and 28 healthy adults.All were tested with China Runjie WJ-1 ERP Instrument,congruent ending words of Chinese idioms(matching)and incongruent ending words of Chinese idioms(mismatching)mode.Results:(1)Compared with healthy adults in the control group,N400 latencies were prolonged in Cz brain regions and amplitudes were decreased period of three groups of patients before taking the medicine.(2)The delay in latencies and the decrease in amplitude of schizophrenia N400 were negatively correlated with the PANSS total score of the neuropsychological scale.(3)The abnormal degree of N400 in bipolar depression group was between unipolar depression group and schizophrenia group.Conclusions:We initially believe that(1)the bipolar depression group may be an intermediate state between unipolar depression and schizophrenia.(2)Bipolar depression with psychotic symptoms may have specific language barriers and N400 abnormalities.(3)After the next ERP follow-up,N400 can be used as a laboratory aid for identifying unipolar depression,bipolar depression and schizophrenia.

关 键 词：BIPOLAR DEPRESSION UNIPOLAR DEPRESSION SCHIZOPHRENIA EVENT-RELATED potential N400 Medical engineering cooperation 

分 类 号：R74[医药卫生—神经病学与精神病学]