营养性复合添加剂对饲喂含黄曲霉毒素B1饲粮生长育肥猪生长性能、抗氧化能力、肝脏功能和毒素残留的影响  

Effects of Nutritional Compound Additives on Growth Performance,Antioxidant Capacity,Liver Function and Toxin Residues of Growing-Finishing Pigs Fed Diets Contaminated with Aflatoxin B1

作　　者：蒲俊宁 原清会 陈代文[1] 田刚[1] 何军[1] 郑萍[1] 毛湘冰[1] 虞洁[1] 黄志清[1] 罗钧秋[1] 罗玉衡[1] 余冰[1] PU Junning;YUAN Qinghui;CHEN Daiwen;TIAN Gang;HE Jun;ZHENG Ping;MAO Xiangbing;YU Jie;HUANG Zhiqing;LUO Junqiu;LUO Yuheng;YU Bing(Key laboratory of Animal Disease-Resistant Nutrition,Sichuan Province,Key laboratory of Animal Disease-Resistant Nutrition and Feed,Ministry of Agriculture and Rural Affairs,Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education,Institute of Animal Nutrition,Sichuan Agricultural University,Ya’an 625014,China)

机构地区：[1]四川农业大学动物营养研究所动物抗病营养四川省重点实验室农业农村部动物抗病营养与饲料重点实验室动物抗病营养教育部重点实验室

出　　处：《动物营养学报》2019年第10期4691-4700,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：科技基础性工作专项(2014FY111000-4);国家科技支撑计划项目(2014BAD13B01)

摘　　要：本试验旨在研究营养性复合添加剂对饲喂含黄曲霉毒素B 1(AFB1)饲粮生长育肥猪生长性能、抗氧化能力、肝脏功能和毒素残留的影响。选取平均体重为(38.06±0.27)kg的健康“杜×长×大”生长育肥猪28头,按照体重相近原则随机分为4组,分别为对照组(基础饲粮)、AFB1组(含AFB1 280μg/kg)、复合添加剂Ⅰ组(AFB1饲粮+0.3%抗氧化复合添加剂)和复合添加剂Ⅱ组(AFB1饲粮+0.3%肠道健康复合添加剂),每组7个重复,每个重复1头猪。试验期102 d。结果表明:与对照组相比,AFB1组51~75 kg生长育肥猪的平均日增重(ADG)显著降低(P<0.05);135 kg时的血浆总超氧化物歧化酶(T-SOD)活性显著降低(P<0.05),血浆丙二醛(MDA)含量显著升高(P<0.05);100 kg时的血浆谷草转氨酶(GOT)活性显著升高(P<0.05);肝脏指数、肝脏和肾脏AFB1和黄曲霉毒素M1(AFM1)含量显著升高(P<0.05),背最长肌AFB1含量显著升高(P<0.05)。与AFB1组相比,复合添加剂Ⅰ组51~75 kg生长育肥猪的ADG显著升高(P<0.05);135 kg时的血浆T-SOD活性显著升高(P<0.05);100 kg时的血浆MDA含量和GOT活性显著降低(P<0.05);肾脏AFM 1和背最长肌AFB1含量显著降低(P<0.05)。与AFB1组相比,复合添加剂Ⅱ组生长育肥猪135 kg时的血浆T-SOD活性显著升高(P<0.05),100和135 kg时的血浆MDA含量显著降低(P<0.05);100 kg时的血浆GOT活性显著降低(P<0.05)。综上所述,饲喂含280μg/kg AFB1饲粮可导致生长育肥猪的生长性能和机体抗氧化能力下降、组织AFB1残留量增加、肝脏功能受损;添加0.3%抗氧化复合添加剂显著降低AFB1在组织中的残留,提高机体抗氧化能力,缓解AFB1对生长育肥猪生长性能和肝脏功能的不良影响;添加0.3%肠道健康复合添加剂显著提高机体抗氧化能力,缓解AFB1对生长育肥猪肝脏的损伤。This experiment was conducted to investigate the effects of nutritional compound additives on growth performance,antioxidant capacity,liver function and toxin residues of growing-finishing pigs fed diets contaminated with aflatoxin B1(AFB1).Twenty-eight healthy Duroc×Landrace×Yorkshire growing-finishing pigs with average body weight of(38.06±0.27)kg were randomly assigned to 4 groups with 7 replicates per group and 1 pig per replicate according to similar body weight.The 4 group were control group(basal diet),AFB1 group(280μg/kg AFB1),compound additive groupⅠ(AFB1 diet+0.3%antioxidant compound additive)and compound additive groupⅡ(AFB1 diet+0.3%intestinal health compound additive),respectively.The experiment lasted for 102 days.The results showed as follows:compared with control group,average daily gain(ADG)at 51 to 75 kg was significantly decreased(P<0.05),plasma total superoxide dismutase(T-SOD)activity was significantly decreased and plasma malondialdehyde(MDA)content was significantly increased at 135 kg(P<0.05),plasma glutamic oxaloacetic transaminase(GOT)activity was significantly increased at 100 kg(P<0.05),and liver index,AFB1 and aflatoxin M1(AFM1)contents in liver and kidney and AFB1 content in longissimus dorsi of growing-finishing pigs in AFB1 group were significantly increased(P<0.05).Compared with AFB1 group,ADG at 51 to 75 kg was significantly increased(P<0.05),plasma T-SOD activity was significantly increased at 135 kg(P<0.05),plasma MDA content and GOT activity were significantly decreased at 100 kg(P<0.05),and AFM 1 content in kidney and AFB1 content in longissimus dorsi of growing-finishing pigs in compound additive groupⅠwere significantly decreased(P<0.05).Compared with AFB1 group,plasma T-SOD activity was significantly increased at 135 kg(P<0.05),plasma MDA content was significantly decreased at 100 and 135 kg(P<0.05),and plasma GOT activity at 100 kg of growing-finishing pigs in compound additive groupⅡwas significantly decreased(P<0.05).In conclusion,dietary 280μg/kg AFB1 can

关 键 词：营养性复合添加剂 黄曲霉毒素B1 生长性能 肝脏功能 毒素残留 生长育肥猪 

分 类 号：S828[农业科学—畜牧学]