关注手性药物:从“反应停事件”说起  

Great Concern for Chiral Pharmaceuticals from the Thalidomide Tragedy

作　　者：章伟光[1] 张仕林 郭栋 赵檑[2] 于腊佳[2] 章慧[2] 何裕建 ZHANG Weiguang;ZHANG Shilin;GUO Dong;ZHAO Lei;YU Lajia;ZHANG Hui;HE Yujian(School of Chemistry and Environment,South China Normal University,Guangzhou 510006,P.R.China;College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,P.R.China;School of Chemical Science,University of Chinese Academy of Sciences,Beijing 100039,P.R.China)

机构地区：[1]华南师范大学化学与环境学院,广州510006 [2]厦门大学化学化工学院,福建厦门361005 [3]中国科学院大学化学科学学院,北京100039

出　　处：《大学化学》2019年第9期1-12,共12页University Chemistry

基　　金：国家自然科学基金(21571070,21273175,51772289);国家基础科学人才培养基金(J1310024);广东省自然科学基金(2018A030313193);广州市科学研究计划重点项目专题(201804020019)

摘　　要：自从20世纪60年代发生“反应停”事件以来,药物手性的研究在新药研发领域引起了极大关注。手性异构体在生物体中可能表现出截然不同的药理、药物动力学、代谢和毒理活性等。近年来结合手性光谱的手性高效液相色谱(HPLC)技术在手性药物的分析、测定和分离等方面得到广泛应用,这对于手性药物对映体含量的检测和质量控制至关重要。Since the Thalidomide tragedy in the 1960s,the issue of chirality has become increasingly important in the fields of novel drug development and pharmaceutical research.Enantiomers may exhibit different pharmacologic,pharmacokinetic,metabolic,and toxicological activity in living organisms.Recently,chiral High-Performance Liquid Chromatography(HPLC)technology combined with chiroptical spectroscopy has been widely used in separation and analysis of chiral compounds,and will play a critical role in the detection and quality control of chiral pharmaceuticals.

关 键 词：手性药物 反应停事件 手性保健品 对映异构体 对映选择性 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]