阿加曲班联合氯吡格雷治疗急性后循环脑梗死的临床效果  

Clinical effect of Argatroban combined with Clopidogrel in the treatment of acute posterior circulation cerebral infarction

作　　者：郭丽莎[1] 孙强[1] 邢惠娟 刘晓琳[1] 方骁[1] GUO Li-sha;SUN Qiang;XING Hui-juan;LIU Xiao-lin;FANG Xiao(Department of Neurology,Dalian Third People′s Hospital,Liaoning Province,Dalian,116000,China)

机构地区：[1]大连市第三人民医院神经内科

出　　处：《中国当代医药》2019年第27期134-136,共3页China Modern Medicine

摘　　要：目的分析阿加曲班联合氯吡格雷治疗急性后循环脑梗死的临床效果。方法选取2017年1月~2018年2月我院收治的67例急性后循环脑梗死患者作为研究对象,采用随机选号的方法分为对照组(35例)与观察组(32例),对照组患者接受阿司匹林联合氯吡格雷治疗,观察组患者接受阿加曲班联合氯吡格雷治疗,比较两组患者的临床疗效、不良反应总发生率和治疗前后的神经功能缺损(NIHSS)评分、生活质量(BI)评分。结果观察组患者疾病的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05);观察组患者治疗后的NIHSS评分低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的BI评分高于对照组,差异有统计学意义(P<0.05)。结论急性后循环脑梗死患者接受阿加曲班联合氯吡格雷治疗,可以显著改善患者的病情,且不良反应较少,值得推广应用。Objective To analyze the clinical effect of Argatroban combined with Clopidogrel in the treatment of acute posterior cerebral infarction.Methods Sixty-seven patients with acute posterior circulation cerebral infarction admitted to our hospital from January 2017 to February 2018 were selected as the subjects.They were divided into control group(35 cases)and observation group(32 cases)by random number selection method.The control group received Aspirin plus Clopidogrel.The observation group received Argatroban plus Clopidogrel.The clinical efficacy,total adverse reaction incidence,neurological deficit(NIHSS)score and quality of life(BI)score were compared between the two groups.Results The total effective rate of the disease in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The NIHSS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The BI score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Patients with acute posterior circulation cerebral infarction receiving Argatroban combined with Clopidogrel can significantly improve the patients′condition and has fewer adverse reactions,which is worthy of being promoted and applied.

关 键 词：急性脑梗死 阿加曲班 氯吡格雷 不良反应 神经功能缺损 生活质量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]