MAOA-uVNTR基因多态性与婴儿气质的相关性研究  

An Association Study of MAOA-uVNTR Gene Polymorphism on Infant Temperament

作　　者：张明浩[1] 郑淑杰[1] ZHANG Minghao;ZHENG Shujie(School of Education science,Ludong University,Yantai 264039,China)

机构地区：[1]鲁东大学教育科学学院

出　　处：《鲁东大学学报（哲学社会科学版）》2019年第5期77-83,共7页Ludong University Journal:Philosophy and Social Sciences Edition

基　　金：教育部人文社科项目“学前儿童欺负行为的发展轨迹及预防研究”(17YJA880097);山东省“十三五”教育科学规划项目“农村学前儿童欺负行为发展轨迹及预防研究”(YZ2017008)

摘　　要：气质影响着儿童的社会性发展,并可以作为儿童后期及成年期某些精神疾病的内表型,因此研究遗传因素对早期婴儿气质的影响极为重要。为考察MAOA基因多态性对婴儿气质的影响,采用问卷与实验室观察法对281名婴儿及其父母进行了研究,并采用聚合酶链式反应(Polymerase Chain Reaction,PCR)对婴儿的单胺氧化酶A基因启动子区的可变重复序列多态性(MAOA-uVNTR)进行基因分型。结果发现,MAOA-uVNTR多态性与女孩的自我调节显著相关,与其它气质维度之间不存在显著相关性,这表明遗传因素影响早期婴儿气质。Temperament influences children's social development and can be an endophenotype of some mental diseases in the late childhood and adulthood.Therefore,it is very important to study the genetic factors influencing early infant temperament.In order to explore the influence of MAOA-uVNTR gene polymorphism on infant temperament,questionnaire and lab observation were used to study 281 infants and their parents,and Polymerase Chain Reaction(PCR)was performed to analyze the genotype of functional gene polymorphisms in the promoter region of monoamine oxidase A gene(MAOA-uVNTR).It is found that MAOA-uVNTR polymorphism is significantly associated with infant girls' self-regulation,but no other associations are found,which suggests that the genetic factors can influence the early infant temperament.

关 键 词：婴儿 气质 MAOA-uVNTR 基因多态性 

分 类 号：B844.12[哲学宗教—发展与教育心理学]