口腔菌群多样性与菌株基因组多态性  

Oral Microbiota Diversity and Bacterial Genomic Polymorphism

作　　者：葛林虎[1] 苏汉福 GE Linhu;SU Hanfu(Key Laboratory of Oral Medicine,Guangzhou Institute of Oral Disease,Affiliated Stomatology Hospital of Guangzhou Medical University,Guangzhou 510182,China)

机构地区：[1]广州医科大学附属口腔医院广州口腔疾病研究所口腔医学重点实验室

出　　处：《口腔医学研究》2019年第10期915-918,共4页Journal of Oral Science Research

摘　　要：口腔菌群是口腔中所有细菌的集合,其不仅在牙周病、龋病等口腔炎症性疾病中具有关键作用,还与动脉粥样硬化、阿尔兹海默症、类风湿性关节炎等口腔外疾病相关。然而,口腔菌群在个体间存在很大的差异。这种差异既表现在群体组成上(多样性),又表现在细菌基因组上(多态性)。口腔菌群多样性和多态性是影响疾病发生发展的重要原因,也是口腔菌群与健康关系研究的重点。本文就目前口腔菌群多样性与多态性研究进展及其在疾病中的作用做一述评。Oral microbiota is the combination of all bacteria living in oral cavity.Recent evidence showed that oral microbiota not only plays key role on oral diseases such as periodontitis and dental caries,but also is associated with systemic diseases like atherosclerosis,Alzheimer's disease,and rheumatoid arthritis.Oral microbiota differs in both bacterial population(diversity)and bacterial genomes(polymorphism)among individuals,which are important factors that impact diseases development.This paper reviews recent progress in understanding of oral microbiota in the aspect of diversity and polymorphism,and their roles in disease development.

关 键 词：口腔菌群 多样性 多态性 疾病 

分 类 号：R78[医药卫生—口腔医学]