种植体骨界面的应力状态对种植体周围骨细胞影响  

Effect of Stress State in Implant-bone Interface on Bone Osteocytes in Peri-implant Bone

作　　者：靳志亨 李清 JIN Zhiheng;LI Qing(The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of Education,Wuhan 430079,China)

机构地区：[1]武汉大学口腔医院修复科湖北省口腔基础医学重点实验室-省部共建国家重点实验室培育基地口腔生物医学教育部重点实验室

出　　处：《口腔医学研究》2019年第10期936-939,共4页Journal of Oral Science Research

基　　金：湖北省自然科学基金(编号:ZRMS2017000043)

摘　　要：目的:通过有限元分析及动物实验研究不同应力状态对种植体周围骨细胞的影响。方法:自制两组种植体(全螺纹组和缺螺纹组),在新西兰兔两侧胫骨骺端分别植入,7、15、30和60 d后处死,取材,硬组织包埋,切片后电镜观察。将胫骨骺端及种植体分别建模,并检测骨力学参数,代入到有限元软件中,模拟种植体植入骨内,分析种植体周围骨应力分布。结果:有限元分析结果发现,两组种植体周围骨在距种植体0.75 mm范围内,全螺纹组应力较高。电镜结果显示,在7 d和15 d时,两组种植体周围骨的骨细胞密度及形态出现差异,随着时间增加,这种差异消失。结论:有限元分析可以模拟种植体植入后初始状态下周围骨的应力状态。骨细胞的生物活性可能与受到的应力刺激密切相关,表现为骨结合早期对应力有较好的响应,出现数目及形态的改变。Objective:To investigate the effect of stress state on bone osteocytes around dental implants using finite element analysis and animal experiment.Methods:The designed implants including full-thread and delete-thread implant were placed in proximal tibial metaphysis of rabbits.The animals were sacrificed at 7 days,15 days,30 days,and 60 days after surgery,and undecalcified tissue sections were prepared for SEM.The finite element models of implants and tibia metaphysis were installed and the process of implantation was simulated by computer-aided design software.The von Mises stress in peri-implant bone were recorded and analyzed.Results:The surrounding bone within 0.75 mm from surface of implant in full-thread implant group exhibited higher von Mises stress than delete-thread implant.The SEM images indicated that the number and morphological of osteocytes between two groups of implants at 7 days and 14 days were significantly different.Conclusion:The FEA can simulate the stress distribution on peri-implant bone in the initial state after implantation.The biological activity of osteocyte may be closely related to the stress state,which demonstrated a better response to stress stimuli in early stage of osseointegration and changes of number and morphology of osteocyte.

关 键 词：有限元分析 应力 骨细胞 

分 类 号：R78[医药卫生—口腔医学]