双环醇治疗抗结核药物导致肝损伤的临床效果观察  

Clinical Effect of Bicyclol in Treatment of Patients with Liver Injury Induced by Anti-tuberculosis Drugs

作　　者：臧珊珊 刘永梅[1] 刘芳[1] 田贞贞 马金彤 张桂珍[1] 吕侯强 ZANG Shan-shan;LIU Yong-mei;LIU Fang;TIAN Zhen-zhen;MA Jin-tong;ZHANG Gui-zhen;LYU Hou-qiang(Department of Tuberculosis Disease,Baoding Infectious Diseases Hospital,Baoding,Hebei 071000,China;Department of Internal Medicine,the Second Hospital of Shijiazhuang,Shijiazhuang 050000,China)

机构地区：[1]保定市传染病医院结核科,河北保定071000 [2]石家庄第二医院内科,石家庄050000

出　　处：《解放军医药杂志》2019年第10期47-50,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省卫生厅科研基金项目(20181037);保定市科技局科技支撑计划项目(18ZF112)

摘　　要：目的观察双环醇治疗抗结核药物导致肝损伤的临床效果。方法选择2015年10月—2018年10月收治的抗结核药物导致肝损伤患者72例为研究对象。根据治疗肝损伤的方法不同分为观察组37例和对照组35例。对照组给予甘草酸二铵治疗,观察组给予双环醇片治疗。观察2组的临床效果以及治疗前后症状积分和肝功能变化情况,并比较2组不良反应发生情况。结果观察组的临床总有效率明显高于对照组(P<0.05)。治疗后,2组的丙氨酸转氨酶、天冬氨酸转氨酶和总胆红素水平均低于治疗前,且观察组均低于对照组(P<0.05)。治疗后2周和4周,2组的症状积分较治疗前均降低,且观察组低于对照组(P<0.05)。2组的不良反应发生情况比较差异无统计学意义(P>0.05)。结论临床应注意观察抗结核治疗患者的病情,定期复查肝功能指标,联合使用保护肝脏药物,以保证治疗的连续性,避免耐药性及急性肝损伤发生。Objective To observe clinical effect of Dicyclol in treatment of patients with liver injury induced by anti-tuberculosis drugs.Methods A total of 72 patients with liver injury induced by anti-tuberculosis drugs admitted during October 2015 and October 2018 were divided into observation group(n=37)and control group(n=35)according to different therapeutic methods.Control group was treated with Diammonium Glycyrrhizinate,while observation group was treated with Dicyclol Tablets.In two groups,clinical effect,symptom score and changes of liver function before and after treatment were observed,and incidence rate of adverse reactions was compared.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,levels of alanine transarninase,aspartate aminotransferase and total bilirubin were significantly lower than those before treatment in two groups,and the levels in observation group were significantly lower than those in control group(P<0.05).After 2 and 4 weeks of treatment,symptom scores were significantly lower than those before treatment in two groups,and the score in observation group was significantly lower than that in control group(P<0.05).There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05).Conclusion In order to ensure continuity of treatment and avoid pathogenesy of drug resistance and acute liver injury,patients'conditions with anti-tuberculosis treatment should be paid attention,and liver function indicators should be regularly reviewed,and protective liver drugs should be used in combination.

关 键 词：抗结核药 药物性肝损伤 双环醇 治疗效果 

分 类 号：R575.1[医药卫生—消化系统]