脂肪干细胞对乳腺癌生物学特性影响的研究进展  

Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer

作　　者：万言 梁至洁[2] 韦长元[1] WAN Yan;LIANG Zhijie;WEI Changyuan(Department of Breast Surgery,Guangxi Medical University Affiliated Tumor Hospital,Nanning 530021,China;Breast Surgery Center,Fifth Affiliated Hospital of Guangxi Medical University,Nanning 530022,China)

机构地区：[1]广西医科大学附属肿瘤医院乳腺外科,南宁530021 [2]广西医科大学第五附属医院乳腺中心,南宁530022

出　　处：《肿瘤防治研究》2019年第10期951-955,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金（81360396; 81860341）;广西科技基础条件平台建设项目（15-235-05）;南宁市科学研究与技术开发计划（zc20153004）;广西研究生教育创新计划项目（YCBZ2018041）;广西医药卫生自筹经费计划课题（Z20180679）;南宁市青年科技创新创业人才培育项目(RC20180201)

摘　　要：干细胞辅助移植技术已广泛应用于体表软组织缺陷整形,在乳腺癌术后重建中的应用成为未来的趋势,其中脂肪干细胞(ADSCs)具有良好的增殖、多向分化以及旁分泌等功能,能优化自体脂肪移植疗效,但其在体外对乳腺癌细胞的增殖、上皮间质化以及乳腺癌新生血管形成都有促进作用,在肿瘤学安全性上存在质疑。本文旨在概述ADSCs在乳房重建中的潜在作用,讨论其对乳腺肿瘤学安全性的影响。Stem cell-assisted transplantation technology has been widely used in superficial soft tissue defect remodeling,and has been the trend of the future in postoperative reconstruction of breast cancer.Adiposederived stem cells(ADSCs)possess excellent abilities of proliferation,multi-differentiation,paracrine and so on,and they are very important in efficacy optimization of autologous fat grafting.However,ADSCs have been proved to promote the proliferation,epithelialization of breast cancer cells and the formation of new blood vessels in breast cancer in vitro,arousing a controversy about oncology safety.This review aims to outline the potential role of ADSCs in breast reconstruction and discuss their safety impact on breast cancer.

关 键 词：脂肪干细胞 乳腺癌 术后重建 肿瘤学安全性 

分 类 号：R737.9[医药卫生—肿瘤]