重组组织型纤溶酶原激活剂对急性缺血性脑卒中患者神经功能、预后的影响  

Effect of recombinant tissue plasminogen activator on neurological function and prognosis in patients with acute ischemic stroke

作　　者：李刚[1] 范其江[1] 马云霞[1] 潘双双[1] 杨淑珍[1] Li Gang;Fan Qijiang;Ma Yunxia;Pan Shuangshuang;Yang Shuzhen(First Ward,Department of Neurology,Binzhou Central Hospital,Binzhou 251700,China)

机构地区：[1]滨州市中心医院神经内科一病区,251700

出　　处：《国际医药卫生导报》2019年第19期3242-3244,共3页International Medicine and Health Guidance News

摘　　要：目的观察重组组织型纤溶酶原激活剂(rt-PA)对急性缺血性脑卒中(AIS)患者神经功能及预后的影响。方法回顾性分析本院2017年1月至2018年6月收治的166例ACI患者的临床资料,据治疗方式分为对照组及观察组,各83例。对照组接受常规AIS治疗,观察组在常规治疗基础上接受早期rt-PA溶栓治疗(发病4.5 h内)。比较两组疗效及预后情况,观察患者美国国立卫生研究院卒中量表(NIHSS)评分变化。结果观察组总有效率高于对照组(P<0.05);观察组预后不良率及病死率低于对照组(P<0.05);两组颅内出血率、症状性内出血率比较,差异无统计学意义(均P>0.05);治疗前,两组NIHSS评分比较,差异无统计学意义(P>0.05);溶栓治疗后24.0 h、14 d,观察组NIHSS评分均低于对照组(均P<0.05)。结论早期rt-PA溶栓治疗ACI效果良好且安全性较高,可有效改善患者神经功能及预后。Objective To observe the effect of recombinant tissue plasminogen activator(rt-PA)on neurological function and prognosis in patients with acute ischemic stroke(AIS).Methods The clinical data of 166 patients with acute cerebral infarct(ACI)admitted to our hospital from January,2017 to June,2018 were retrospectively analyzed.According to the treatment methods,they were divided into a control group and an observation group,83 cases for each group.The control group was given routine treatment for AIS.The observation group was given early rt-PA thrombolysis on the basis of routine treatment(within 4.5 hours of onset).The efficacies and prognosis of the two groups were compared.The score changes in the National Institutes of Health Stroke Scale(NIHSS)were observed.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The poor prognosis rate and mortality of the observation group were lower than those of the control group(both P<0.05).There were no statistical differences in the rates of intracranial hemorrhage and symptomatic internal hemorrhage between the two groups(both P>0.05).There was no statistical difference in the NIHSS score between the two groups before the treatment(P>0.05).The scores of NIHSS 24.0 h and 14 d after thrombolysis were lower in the observation group than in the control group(both P<0.05).Conclusion Early rt-PA thrombolysis is effective and safe in the treatment of ACI,which can effectively improve the patients’neurological function and prognosis.

关 键 词：AIS RT-PA 神经功能 预后 

分 类 号：R74[医药卫生—神经病学与精神病学]