急性脑梗死患者NT-proBNP、Hcy及D-D水平变化及其与神经损伤的关系  

Changes of NT-proBNP, Hcy and D-D levels in patients with acute cerebral infarction and their relationship with nerve injury

作　　者：高洁[1] 吕静[1] 王禺[1] GAO Jie;LYU Jing;WANG Yu(Clinical Laboratory Department,Xi'an No.1 Hospital,Xi'an 710000,China)

机构地区：[1]西安市第一医院检验科

出　　处：《临床医学研究与实践》2019年第30期36-37,共2页Clinical Research and Practice

基　　金：陕西省科学技术研究发展计划项目(No.2015SF229)

摘　　要：目的研究急性脑梗死(ACI)患者NT-proBNP、Hcy及D-D水平变化及其与神经损伤的关系。方法选取本院收治的ACI患者120例设为ACI组,根据NIHSS评分将其分为A组(62例,NHISS评分<4分)、B组(36例,NHISS评分4~15分)及C组(22例,NIHSS评分>15分)。另选取同期入院体检的健康志愿者60例作为对照组。比较各组之间NT-proBNP、Hcy、D-D水平,分析上述指标与NHISS评分之间的关系。结果ACI组的NT-proBNP、Hcy、D-D水平显著高于对照组(P<0.05)。A组患者的NT-proBNP、Hcy、D-D水平明显低于B组和C组(P<0.05);B组NT-proBNP、Hcy、D-D水平明显低于C组(P<0.05)。NT-proBNP、Hcy、D-D水平与NIHSS评分呈正相关(P<0.05)。结论NT-proBNP、Hcy、D-D水平变化与ACI患者的病情发生发展、神经损伤关系密切,可将NT-proBNP、Hcy、D-D作为临床检验中评估ACI的有效指标。Objective To study the changes of NT-proBNP,Hcy and D-D levels in patients with acute cerebral infarction(ACI)and their relationship with nerve injury.Methods A total of 120 patients with ACI admitted in our hospital were selected as ACI group.According to NIHSS score,patients were divided into group A(62 cases,NHISS score<4 points),group B(36 cases,NHISS score of 4-15 points)and group C(22 cases,NIHSS score>15 points).Another 60 healthy volunteers were selected as control group.The levels of NT-proBNP,Hcy and D-D were compared among the groups,and the relationship between the above indicators and NHISS score were analyzed.Results The levels of NT-proBNP,Hcy and D-D in the ACI group were significantly higher than those in the control group(P<0.05).The levels of NT-proBNP,Hcy and D-D in the group A were significantly lower than those in the group B and C(P<0.05);the levels of NT-proBNP,Hcy and D-D in the group B were significantly lower than those in the group C(P<0.05).The levels of NT-proBNP,Hcy and D-D were positively correlated with NIHSS scores(P<0.05).Conclusion The changes of NT-proBNP,Hcy and D-D levels are closely related to the occurrence and development of ACI and nerve injury.NT-proBNP,Hcy and D-D can be used as effective indicators to evaluate ACI in clinical tests.

关 键 词：急性脑梗死 N-末端脑钠肽前体 同型半胱氨酸 D-二聚体 神经损伤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]