分数低频振幅在评价轻度认知功能损害并发抑郁患者静息状态下脑功能的应用  

Fractional amplitude of low-frequency fluctuation on MRI in patient of mild cognitive impairment accompanies depression

作　　者：葛怀志 陈久尊[1] 徐雷[1] 孙素[1] 林锋[1] 吴爱琴[1] GE Huaizhi;CHEN Jiuzun;XU Lei(Department of Radiology,the Second Affiliated and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学附属第二医院放射科

出　　处：《浙江医学》2019年第20期2173-2176,2180,共5页Zhejiang Medical Journal

基　　金：温州医科大学附属第二医院、育英儿童医院临床研究专项基金项目(SAHoWMU-CR2017-05-407)

摘　　要：目的 研究轻度认知功能损害(MCI)并发抑郁患者静息状态下脑区分数低频振幅(fALFF)的特点及脑功能情况,以期为MCI患者并发抑郁的早期诊断和临床治疗提供参考.方法 将34例MCI患者中16例并发抑郁者纳入D-MCI组,18例未并发抑郁者纳入nD-MCI组.于平静状态下分别进行3.0T脑部MRI检测并获取相关数据,采用双样本t检验分析两组相对应各体素的fALFF值差异,以寻找fALFF值存在差异的脑区.结果 与nD-MCI组比较,D-MCI组患者右侧中央后回的fALFF值降低(差异体素280个,t=-4.2889),而右侧丘脑的fALFF值显著增高(差异体素572个,t=2.7208).结论 MCI并发抑郁患者脑部右侧中央后回和右侧丘脑存在fALFF异常,提示情感及认知网络障碍可能参与其中.Objective To investigate the characteristics of fractional amplitude of low-frequency fluctuations(fALFF)on resting MRI and brain function in patients with mild cognitive impairment(MCI)complicated with depression at rest.Methods Thirty four patients with MCI were enrolled in the study,including 16 cases with depression(D-MCI group),and 18 patients without depression(nD-MCI group).The resting MRI scan were obtained by the 3.0T MR scanner.The two-sample t-test was used to analyze the difference in fALFF values of the corresponding voxels between the two groups.Results Compared with the nD-MCI group,the fALFF value of the right central posterior gyrus of the D-MCI group was decreased(280 different voxels,t=-4.2889),while the fALFF value of the right thalamus was significantly increased(572 voxels,t=2.7208).Conclusion There are abnormal fALFF in the central posterior gyrus and thalamus in patients with MCI,suggesting that affective and cognitive network disorders may be involved in depression.

关 键 词：静息态功能MRI 抑郁 分数低频振幅 轻度认知功能损害 

分 类 号：R74[医药卫生—神经病学与精神病学]