性激素在视神经疾病中的研究进展  

Research progress on sex hormones in optic nerve diseases

作　　者：李艳霞 聂圣琼 牛灵芝 郑雅娟[1] Li Yanxia;Nie Shengqiong;Niu Lingzhi;Zheng Yajuan(Department of Ophthalmology,Second Hospital of Jilin University,Changchun 130000,China)

机构地区：[1]吉林大学第二医院眼科中心

出　　处：《新医学》2019年第11期801-804,共4页Journal of New Medicine

基　　金：吉林省卫生技术创新项目（20165047）

摘　　要：近年来,性激素在视神经疾病中所起的作用越来越受到关注。例如雌激素可减轻青光眼患者的视神经损伤并且有一定程度的降眼压作用,血清孕酮水平的降低与非动脉炎性前部缺血性视神经病变密切相关,男性相对更易患Leber遗传性视神经病变,以及多发硬化相关性视神经炎的复发率存在性别差异等,提示性激素在视神经疾病中扮演重要角色。该文就性激素在视神经疾病中的作用及其机制进行综述。In recent years,the role of sex hormones in optic nerve diseases has captivated increasing attention.Estrogen can mitigate optic nerve damage and exert certain effect on intraocular pressure reduction in patients with glaucoma.The decrease of serum progesterone level is closely correlated with non-arteritic anterior ischemic optic neuropathy.Men are relatively more susceptible to Leber hereditary optic neuropathy than female counterparts.Gender differences exist in the recurrence rate of multiple sclerosis-associated optic neuritis.All these factors prompt that sex hormones play a pivotal role in optic nerve diseases.In this article,the role and mechanism of sex hormones in optic nerve diseases were reviewed.

关 键 词：性激素 视神经疾病 青光眼 LEBER遗传性视神经病变 非动脉炎性前部缺血性视神经病变 多发硬化相关性视神经炎 

分 类 号：R73[医药卫生—肿瘤]