苯佐卡因衍生物的合成研究  

Synthesis of benzocaine derivatives

作　　者：刘冰 周勇 Liu Bing;Zhou Yong(School of Chemistry and Chemical Engineering,Xinxiang University,Xinxiang 453000,China)

机构地区：[1]新乡学院化学化工学院

出　　处：《河南师范大学学报（自然科学版）》2019年第6期71-75,共5页Journal of Henan Normal University(Natural Science Edition)

基　　金：河南省科技攻关项目(192102310297)

摘　　要：以苯佐卡因为原料,通过微通道反应器,使苯佐卡因与不同的溴代衍生物发生取代反应,得到了一系列结构新颖的苯佐卡因衍生物,研究了反应条件对单取代和双取代反应的影响,最后对得到的衍生物进行初步生物活性测试,发现部分化合物对金黄色葡萄球菌其有一定的抗菌活性.With benzocaine as starting material,a series of novel brominated derivatives were synthesized via substitution reaction in the micro-channel reactor.The effect of reaction condition on the preparation was discussed.The result of preliminary bioassay showed that some of the derivatives had antibacterial activity against staphylococcus aureus.

关 键 词：苯佐卡因 溴代衍生物 抗菌活性 

分 类 号：R914.5[医药卫生—药物化学]