视网膜神经节细胞凋亡机制的研究进展  

The research progress of apoptosis mechanism of retinal ganglion cells

作　　者：李强 王红义 任丽[3] 段俊国 LI Qiang;WANG Hongyi;Ren Li;Duan Junguo(College of Ophthalmology,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,610075;Wuhou District Yulin Community Health Service Center,Chengdu,Sichuan,610041;Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,610075)

机构地区：[1]成都中医药大学眼科学院,四川成都610075 [2]成都市武侯区玉林社区卫生服务中心,四川成都610041 [3]成都中医药大学,四川成都610075

出　　处：《中医眼耳鼻喉杂志》2019年第2期96-98,共3页Journal of Chinese Ophthalmology and Otorhinolaryngology

基　　金：教育部高等学校博士学科点专项科研基金(新教师类)项目(编号:20135132120003);四川省科技计划项目(编号:2018JY0314);成都市人口和计划生育委员会项目(编号:2015019)

摘　　要：青光眼是指与眼压升高有关的以视网膜神经纤维萎缩、视盘凹陷和视野缺损为主要特征的一组疾病,为临床常见病和主要致盲眼病。视网膜神经节细胞凋亡是其病理基础。目前治疗青光眼仍然以降低眼压为目的,但降低眼压并非对所有患者都有效。很多学者开始关注引起视网膜神经节细胞凋亡凋亡的机制,寻找新的治疗措施。本文从分子生物学角度总结视网膜神经节细胞凋亡的凋亡机制,为青光眼的新治疗方案提供依据。Glaucoma refers to a group of diseases associated with elevated intraocular pressure and characterized by retinal nerve fiber atrophy,optic disc depression and visual field defect.It is a common clinical disease and a major cause of blindness.Retinal ganglion ceils(RGCs)apoptosis is the basis of their pathology.At present,glaucoma treatment is still aimed at lowering Intraocular pressure(iop),but lowering iop is not effective for all patients.Many scholars began to pay attention to the mechanism of RGC apoptosis and search for new therapeutic measures.This article summarizes the apoptosis mechanism of RGC from the perspective of molecular biology,and provides the basis for the new treatment of glaucoma.

关 键 词：视网膜神经节细胞 凋亡机制 

分 类 号：R774[医药卫生—眼科]