202例肝功能异常患者病因分析  

Etiology of 202 patients with abnormal liver function tests

作　　者：丁利敏 王飞[1] 朴莲淑[1] 张孟 刘城 李芊蔚[1] 徐德魁[1] 于庆功 Ding Limin;Wang Fei;Piao Lianshu(Department of Gastroenterology,Zhongshan Hospital,Affiliated to Dalian University,Dalian 116000,Liaoning Province,China)

机构地区：[1]大连大学附属中山医院消化内科

出　　处：《实用肝脏病杂志》2019年第6期856-859,共4页Journal of Practical Hepatology

摘　　要：目的探讨肝功能异常的常见病因。方法2011年6月~2018年6月收治的202例肝功能异常患者,常规进行病因筛查。结果在202例住院的肝功能异常患者中,脂肪性肝病(NAFLD)62例(30.7%)、药物性肝损害(DILI)56例(27.7%)、自身免疫性肝病(AILD)18例(8.9%)、嗜肝病毒感染18例(8.9%)、肿瘤9例(4.5%)、肝硬化11例(5.5%)、胆道系统感染11例(5.5%)、非嗜肝病毒感染1例(0.5%)、中毒1例(0.5%)、营养不良2例(1.0%)和病因不明13例(6.4%);青年组NAFLD、DILI和嗜肝病毒感染构成比分别为49.4%、16.9%和10.8%,中年组DILI、脂肪性肝病和AILD构成比分别为34.3%、25.4%和10.5%,老年组DILI、AILD和肿瘤构成比分别为36.5%、15.4%和13.5%;男性NAFLD、DILI和嗜肝病毒感染构成比分别为43.6%、20.0%和15.8%,女性DILI、脂肪性肝病和AILD构成比分别为35.6%、17.8%和14.9%。结论导致肝功能异常的病因较多,不同年龄和不同性别人群常见病因有所不同。Objective To investigate the etiology of 202 patients with abnormal liver function tests.Methods 202 patients with abnormal liver function tests were admitted to our Department of Gastroenterology,Zhongshan Hospital between June 2011 and June 2008.The etiologic examination was routinely conducted.Results Out of the 202 patients with abnormal liver function tests,fatty liver disease was found in 62 cases(30.7%),drug-induced liver injuries(DILI)in 56 cases(27.7%),autoimmune liver disease(AILD)in 18 cases(8.9%),hepatotropic virus infection in 18 cases(8.9%),tumor in 9 cases(4.5%),liver cirrhosis in 11(5.5%),bile duct infection in 11(5.5%),non-hepatotropic virus infection in 1(0.5%),toxic injuries in 1(0.5%),malnutrition in 2(1.0%)and liver injury with unknown cause in 13(6.4%);the percentages of NAFLD,DILI and hepatotropic virus infection in youth accounted for 49.4%,16.9%and 10.8%,the percentages of DILI,NAFLD and AILD in middle aged group accounted for 34.3%,25.4%and 10.5%,and the percentages of DILI,AILD and tumor in elderly group accounted for 36.5%,15.4%and 13.5%;the percentages of NAFLD,DILI and hepatotropic viral infection in men accounted for 43.6%,20.0%nd 15.8%,and those of DILI,NAFLD and AILD in women accounted for 35.6%,17.8%and 14.9%.Conclusion The causes of abnormal liver function tests are complex and diverse,and the common causes of it in different ages and different genders differ,which might help the clinicians to deal with them.

关 键 词：肝功能异常 病因 分析 

分 类 号：R57[医药卫生—消化系统]