肉桂酸合成实验的改进  

Improvement of cinnamic acid synthesis experiment

作　　者：蒋成君[1] 程桂林 JIANG Cheng-jun;CHENG Gui-lin(School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023,China;Pharmaceutical Research Center of Public Platform,Zhejiang Chinese Medical University,Hangzhou 311400,China)

机构地区：[1]浙江科技学院生物与化学工程学院,浙江杭州310023 [2]浙江中医药大学中医药科学院,浙江杭州311400

出　　处：《实验室科学》2019年第5期37-38,44,共3页Laboratory Science

基　　金：浙江科技学院课程建设项目(项目编号:0101103464)

摘　　要：肉桂酸合成实验是有机化学实验教学中的重要实验。对肉桂酸的合成进行了改进,以苯甲醛与乙酸酐为反应物,氯化胆碱-尿素低共熔溶剂为反应溶剂和催化剂,Perkin反应制备肉桂酸。简化了后处理步骤,加水、过滤即可直接得到产物。滤液用乙酸乙酯萃取除杂后,可回收氯化胆碱-尿素,重复使用。改进的方法避免高温,减少了副反应的发生,改善了操作环境,操作简单、收率高、实用性强、值得推广。Synthesis of cinnamic acid is an important experiment in the organic chemistry experimental teaching.Benzaldehyde and acetic anhydride as reactants,choline chloride-urea as the solvent and catalyst,synthesis of cinnamic acid by Perkin reaction.This method avoid high temperatures,which causes more side reactions and the volatilization of irritating substances.Add water and filter to obtain product.The filtrate is extracted with ethyl acetate to remove impurities,and the choline chloride-urea can be recovered and reused.The improved method is simple in operation,high in yield,highly practical,worthy of promotion.

关 键 词：肉桂酸 PERKIN反应 低共融溶剂 

分 类 号：G482[文化科学—教育学]