放疗联合免疫检查点抑制剂治疗非小细胞肺癌研究进展  

Advances in radiotherapy combined with immunologic checkpoint inhibitors in the treatment of non-small cell lung cancer

作　　者：刘晓丽 李莉 袁双虎[1,2] Feng-Ming(Spring)Kong 于金明 LIU Xiao-li;LI Li;YUAN Shuang-hu;Feng-Ming(Spring)Kong;YU Jin-ming(Department of Clinical Medicine,Shandong University,Ji'nan 250117,China;Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Shandong,Ji'nan 250117,China;School of Medicine and Life Sciences,University of Ji'nan,Shandong Academy of Medical Sciences,Ji'nan 250022,China;Department of Radiation Oncology,University Hospitals/Seidman Cancer Center and Case Comprehensive Cancer Center,Case Western Reserve University,OH,Cleveland 44106,United States)

机构地区：[1]山东大学临床医学院,济南250117 [2]山东省肿瘤防治研究院(山东省肿瘤医院)山东第一医科大学(山东省医学科学院)放疗科,济南250117 [3]济南大学山东省医学科学院医学与生命科学学院,济南250022 [4]凯斯西储大学赛德曼癌症中心和病例综合癌症中心放疗科,美国俄亥俄州克里夫兰44106

出　　处：《肿瘤综合治疗电子杂志》2019年第4期1-5,I0002,共6页Journal of Multidisciplinary Cancer Management(Electronic Version)

基　　金：国家自然科学基金(NSFC81872475,NSFC81372413);国家重点研发计划(2016YFC0904700);山东省重点研发计划(2017CXGC1209,2017GSF18164);山东省自然科学杰出青年基金(JQ201423);济南市临床医学科技创新计划(201704095)

摘　　要：肺癌是世界上常见的致死性癌症之一,其中85%的肺癌为非小细胞肺癌(non-small cell lung cancer,NSCLC)。目前放疗是NSCLC主要的治疗手段之一。随着免疫治疗的发展,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已成为部分晚期NSCLC患者的一线治疗。研究发现放疗与免疫治疗具有协同效应,能够改善NSCLC患者的生存。众多研究探索了放疗联合ICIs治疗NSCLC的安全性及有效性,本文就放疗联合ICIs治疗NSCLC的研究进展做一综述。Lung cancer is one of the most common fatal cancers in the world,85%of which are non-small cell lung cancer(NSCLC).At present,radiotherapy is one of the main treatment methods for NSCLC.With the development of immunotherapy,immune checkpoint inhibitors(ICIs)have become the first-line treatment for some advanced NSCLC patients.Studies have found that radiotherapy and immunotherapy have synergistic effects and can improve the survival of NSCLC patients.Numerous studies have explored the safety and efficacy of radiotherapy combined with ICIs in the treatment of NSCLC.This article reviews the research progress of radiotherapy combined with ICIs in the treatment of NSCLC.

关 键 词：非小细胞肺癌 放射治疗 免疫治疗 免疫检查点抑制剂 

分 类 号：R73[医药卫生—肿瘤]