术前血清直接胆红素与肝细胞癌的病理特征及预后的关系  

Relationship between preoperative serum direct bilirubin and pathological features and prognosis of hepatocellular carcinoma

作　　者：赵媛 王夺 罗涛 陈洁[1] 刘军杰[2] 陈苗[2] 黎乐群[1] Zhao Yuan;Wang Duo;Luo Tao;Chen Jie;Liu Junjie;Chen Miao;Li Lequn(Department of Hepatobiliary Surgery,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China;Department of Ultrasound,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院肝胆外科,南宁530021 [2]广西医科大学附属肿瘤医院超声诊断科,南宁530021

出　　处：《广西医科大学学报》2019年第10期1565-1568,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81860512);广西自然科学基金资助项目(No.2016GXNSFBA380194);广西科技计划资助项目(No.桂科AB18126032)

摘　　要：目的:探讨术前血清直接胆红素(DBIL)与肝细胞癌的病理特征及预后的关系。方法:回顾性分析2014年1月至2016年8月在广西医科大学附属肿瘤医院接受手术的186例肝癌患者的临床资料,其中DBIL阴性组135例,DBIL阳性组51例。分析术前血清DBIL水平与临床病理特征之间的关系。应用Kaplan-Meier法计算两组的总体生存率并用Log-rank检验分析两组的生存差异。采用Cox比例风险模型对肝癌患者预后的影响因素进行单因素和多因素分析。结果:血清DBIL水平与性别、民族、Child-Pugh分级、癌胚抗原(CEA)等临床病理学特征均有关(均P<0.05)。生存分析显示,DBIL阳性组较DBIL阴性组的总体生存率更低。单因素和多因素分析结果表明,术前血清DBIL水平是影响肝癌患者术后总体生存率的独立危险因素(P<0.05)。结论:术前血清DBIL升高是影响肝癌预后不良的独立危险因素。Objective:To explore the relationship between preoperative serum direct bilirubin and the pathological features and prognosis of hepatocellular carcinoma.Methods:The clinical data of 186 patients with hepatocellular carcinoma who underwent surgery in our hospital from January 2014 to August 2016 were retrospectively analyzed.The patients were divided into DBIL-negative group(135 cases)and DBIL-positive group(51 cases).The relationship between preoperative serum DBIL level and clinicopathological features was analyzed.The overall survival of the two groups was evaluated by Kaplan-Meier method.The factors influencing the prognosis of patients was analyzed by univariate and multivariate analysis.Results:Serum DBIL level was associated with gender,ethnicity,Child-Pugh classification,and carcinoembryonic antigen(CEA)(P<0.05).The overall survival rate was lower in the DBIL-positive group than that in the DBIL-negative group.Univariate and multivariate analysis showed that preoperative serum DBIL level was an independent risk factor affecting overall survival of patients with hepatocellular carcinoma.Conclusion:Increase of preoperative serum DBIL level was an independent risk factor for the poor prognosis of hepatocellular carcinoma.

关 键 词：肝细胞癌 直接胆红素 预后 

分 类 号：R735.7[医药卫生—肿瘤]