五加参归芪精改善睡眠功能的时效关系研究  

Time-effect Relationship of Wujiashenguiqijing in Improving Sleep Function

作　　者：徐杰 姜文月 王宝成 王美慧 邢成 肖俊美 杨明爽 李芯茹 Xu Jie;Jiang Wenyue;Wang Baocheng;Wang Meihui;Xing Cheng;Xiao Junmei;Yang Mingshuang;Li Xinru(Jilin Modern Chinese Medcine Engineering and Research Center Co.,Ltd,C hangchun 130012,China;Tongyao Pharmaceutical Group Co.,L td.,T onghua 134001,China)

机构地区：[1]吉林省现代中药工程研究中心有限公司,吉林长春130012 [2]通药制药集团股份有限公司,吉林通化134001

出　　处：《亚太传统医药》2019年第10期23-25,共3页Asia-Pacific Traditional Medicine

基　　金：吉林省科技发展计划项目(YYZX201707)

摘　　要：目的:研究五加参归芪精改善睡眠功能的时效关系。方法:采用戊巴比妥钠协同睡眠试验,设立空白组、阳性药组、五加参归芪精低剂量和高剂量组,于给药后第3、7、14、21天检测小鼠睡眠百分率、睡眠持续时间及睡眠潜伏期等指标,考察该药在不同给药时间条件下的改善睡眠功能药效作用,明确时效关系。结果:在设置的时效考察周期内,五加参归芪精低剂量组(1.50 mL/kg/d)改善睡眠未见显著性差异,而五加参归芪精高剂量组(3.03 mL/kg/d)从给药第3天即开始起效,随着用药时间的延长,始终维持显著的药效作用,呈现良好的时效关系。结论:五加参归芪精具有显著的改善睡眠功能,在3、7、14、21天实验周期内,高剂量组从第3天开始出现显著、稳定的药效作用,改善睡眠功能具有时效相关性。Objective:To investigate the time-effect relationship of Wujiashenguiqijing on improving sleep function.Methods:The pentobarbital sodium collaborative sleep experiment was adopted.The blank group,model group,positive drug group,low-dose and high-dose group of Wujiashenguiqijing were set up.Sleep percentage,sleep duration and sleep latency of mice were measured at 3,7,14 and 21 d after administration.The pharmacodynamic effects of the product on improving sleep function under different administration time were investigated,and the time-effect relationship was clarified.Results: There was no significant difference in sleep improvement the low-dose group of Wujiashenguiqijing(1.50 mL/kg/d),and the high dose group of Wujiashenguiqijing(3.03 mL/kg/d)began to take effect on the 3 d of administration.With the prolongation of the medication time,the significant effect was maintained and showed a good time-effect relationship.Conclusion:Wujiashenguiqijing had the significant pharmacological effects of improving sleep function.In the 3,7,14 and 21 d experimental cycle,the high-dose group had significant and stable pharmacodynamic effects from 3 d,and the effect of improving sleep had a time-effect relationship.

关 键 词：五加参归芪精 改善睡眠 时效关系 

分 类 号：R256.23[医药卫生—中医内科学]