结肠癌组织c-Myc蛋白表达临床意义  

Prognostic value of c-Myc protein expression in colon cancer

作　　者：高翔[1] 陆庭勋[1] 刘彦魁 葛晓松[1] 刘芬 华东[1] GAO Xiang;LU Ting-xun;LIU Yan-kui;GE Xiao-song;LIU Fen;HUA Dong(Affiliated Hospital of Jiangnan University,Wuxi 214062,P.R.China)

机构地区：[1]江南大学附属医院肿瘤内科,江苏无锡214062 [2]江南大学附属医院病理科,江苏无锡214062 [3]江南大学附属医院肿瘤研究所,江苏无锡214062

出　　处：《中华肿瘤防治杂志》2019年第17期1263-1266,1273,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金青年基金（81502042）;江苏省自然科学基金青年基金（BK20140171）;无锡市卫计委卫生科研项目（Q201731）

摘　　要：目的c-Myc蛋白在肿瘤中异常表达,与肿瘤发生发展密切相关。本研究探讨c-Myc异常表达在结肠癌组织中的临床预后价值。方法收集2002-11-18-2008-12-24江南大学附属医院病理科192例结肠癌石蜡标本及相应癌旁组织(距癌组织5cm),免疫组织化学法检测结肠癌组织及癌旁组织中c-Myc蛋白表达,分析c-Myc蛋白表达与患者临床病理学特征及预后关系。结果结肠癌组织中c-Myc蛋白主要定位于腺癌细胞核,其阳性率为29.7%(57/192)。c-Myc阳性患者的临床病理学特征与c-Myc阴性患者差异无统计学意义。c-Myc阳性患者中位总生存期(overall survival,OS)为52.9个月,短于c-Myc阴性患者的57.1个月,P=0.002。无肠外转移灶的结肠癌患者中,c-Myc阳性患者5年OS率(64.1%)低于c-Myc阴性患者(80.3%),差异有统计学意义,P=0.03;有肠外转移灶的结肠癌患者中,c-Myc阳性患者中位OS为27.7个月,稍短于c-Myc阴性患者的31.8个月,但差异无统计学意义,P=0.21。Cox多因素回归分析证实,c-Myc阳性(HR=2.66,95%CI:1.35~5.21,P=0.005)是影响结肠癌患者预后的独立危险因素。结论结肠癌组织c-Myc表达水平与患者不良预后相关,在预测结肠癌患者的预后上具有一定的临床价值。OBJECTIVE c-Myc protein is abnormally expressed in tumors and is closely related to tumorigenesis and development.This study was to explore the clinical prognostic value of abnormally expressed c-Myc in colon cancer.METHODS Totally 192 paraffin samples of colon cancer and paracancerous tissues(5 cm from cancer tissue)were collected from the Department of Pathology,Affiliated Hospital of Jiangnan University from 2002-11-18 to 2008-12-24.The expressions of c-Myc protein in colon cancer tissues and adjacent tissues were detected by immunohistochemistry(IHC).The relationship between c-Myc expression and clinical pathological features and prognosis of patients was analyzed.RESULTS The positive rate of c-Myc protein in colon cancer tissues was 29.7%(57/192),and c-Myc was localized to the nucleus of adenocarcinoma cells.The clinicopathological features of c-Myc-positive patients were not significantly different from those of c-Myc-negative patients.The median Overall Survival(OS)of c-Myc-positive patients(52.9 months)was significantly shorter than that of c-Myc-negative patients(57.1 months)(P=0.002).In patients of colon cancer without extraintestinal metastases,the 5-year OS rate of c-Myc-positive patients(64.1%)was significantly lower than that of c-Myc-negative patients(80.3%)(P=0.03);in patients of colon cancer with extraintestinal metastases,the median OS of c-Myc-positive patients(27.7 months)was slightly shorter than that of c-Myc-negative patients(31.8 months),but the difference was not significant(P=0.21).Cox multivariate regression analysis confirmed c-Myc positive(HR=2.66,95%CI:1.35-5.21,P=0.005)was an independent risk factor for prognosis of colon cancer patients.CONCLUSION The expression of c-Myc in colon cancer may be related to the poor prognosis of patients,and it has certain clinical value in predicting the prognosis of colon cancer patients.

关 键 词：结肠癌 预后 转移 C-MYC 

分 类 号：R735.3[医药卫生—肿瘤]