甲胎蛋白联合血清异常凝血酶原检测诊断原发性肝癌的价值分析  

Analysis of the value of alpha-fetoprotein combined with serum abnormal prothrombin in the diagnosis of primary liver cancer

作　　者：方先松[1] 温小云[2] 叶建明[3] Fang Xiansong;Wen Xiaoyun;Ye Jianming(Department of Blood Transfusion Room,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000,China;Department of Clinical Laboratory,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000,China;Department of Oncology,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣南医学院第一附属医院输血科,江西赣州341000 [2]赣南医学院第一附属医院检验科,江西赣州341000 [3]赣南医学院第一附属医院肿瘤科,江西赣州341000

出　　处：《当代医学》2019年第32期38-40,共3页Contemporary Medicine

摘　　要：目的探究甲胎蛋白联合血清异常凝血酶原检测在原发性肝癌诊断中的价值。方法选择本院2017年8月至2018年10月收治的80例原发性肝癌患者作为研究组、80例非原发性肝癌的消化系统疾病患者作为良性对照组以及80例在本院体检健康者作为对照组。采用酶联免疫吸附法检测3组血清中的血清异常凝血酶原,采用电化学发光法测定3组的甲胎蛋白水平。对原发性肝癌患者进行相对应的治疗,治疗完成后再检测原发性肝癌患者的血清甲胎蛋白、血清异常凝血酶原水平。结果研究组患者的血清甲胎蛋白和血清异常凝血酶原水平明显高于良性对照组患者和对照组,组间比较差异具有统计学意义(P<0.05);对原发性肝癌患者进行系统的治疗后,再次检测发现,患者的血清甲胎蛋白、血清异常酶原水平均出现明显下降,与治疗前相比差异具有统计学意义(P<0.05)。结论甲胎蛋白和血清异常凝血酶原对于原发性肝癌的具有特异性的诊断价值,并且能够较好的反映原发性肝癌患者的临床治疗效果。Objective To explore the value of alpha-fetoprotein in the diagnosis of primary liver cancer.Methods 80 patients with primary liver cancer from August 2017 to October 2018 were selected as the study group,80 non-primary liver cancer patients with digestive system disease as the benign control group and 80 normal patients in our hospital as the control group.Serum abnormal prothrombin in serum of three groups was detected by enzyme-linked immunosorbent assay,and the level of alpha-fetoprotein in three groups was determined by electrochemical luminescence method.In the treatment of primary liver cancer patients,the serum alpha-fetoprotein and serum abnormal prothrombin level in patients with primary liver cancer were detected after treatment.Results The levels of serum alpha-fetoprotein and serum abnormal prothrombin in the study group were significantly higher than those in the benign control group and control group(P<0.05).After systematic treatment of patients with primary liver cancer,it was found that the levels of serum alpha-fetoprotein and serum abnormal prothrombin in these patients were significantly lower than those before treatment(P<0.05).Conclusion The specific diagnostic value of alpha-fetoprotein and serum abnormal prothrombin in primary liver cancer,and can be used in the treatment of primary liver cancer.

关 键 词：甲胎蛋白 血清异常凝血酶原 原发性肝癌 价值 

分 类 号：R73[医药卫生—肿瘤]