STEAP4基因多态性与新疆维吾尔族人群超重及肥胖的相关性研究  

Association of STEAP4 gene polymorphism with overweight and obesity in Xinjiang Uygur population

作　　者：朱晴[1] 常桂娟[1] 洪静[1] 李南方[1] ZHU Qing;CHANG Guijuan;HONG Jing;LI Nanfang(Hypertension Center,People's Hospital of Xinjiang Uygur Autonomous Region,Hypertension Institute of Xinjiang,Xinjiang,Urumqi,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院高血压中心新疆高血压研究所

出　　处：《新疆医学》2019年第8期765-769,共5页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区自然科学基金青年基金项目(项目编号:2018D01C117)

摘　　要：目的探究前列腺六次跨膜上皮抗原4(STEAP4)基因多态性是否与新疆维吾尔族人群的超重及肥胖相关。方法研究对象来自一项关于新疆和田地区维吾尔族人肥胖等代谢性疾病的横断面调查研究。收集他们的一般资料(性别、年龄、身高、体重、BMI、血压水平及血液标本进行肝肾功离子、血脂、血糖、胰岛素等指标测定。按照BMI水平进行分组:BMI<25 kg/m^2为非肥胖组(893例);BMI≥25 kg/m^2为超重及肥胖组(1155例)。采用TaqMan-PCR方法对两组人群的STEAP4基因的3个基因多态性位点(rs8122、rs34741656、rs1981529)进行基因型鉴定。结果STEAP4基因的rs1981529的基因型(TT,TC,CC)和等位基因(T,C)在两组之间均存在统计学差异(P<0.001)。CC基因型频率在非肥胖组高于超重及肥胖组(4.4%vs 2.0%)。rs8122基因型(AA、AG、GG)和等位基因(A、G)在两组之间也存在统计学差异(P<0.05);而rs34741656的基因型(AA、AG、GG)和等位基因(A、G)在两组之间无统计学差异(P>0.05)。然而,单因素logistic回归分析显示:仅rs1981529的CC基因型可降低患超重及肥胖的风险(OR:0.410,95%CI:0.208-0.808,P=0.010);校正混杂因素后,上述关联性仍存在统计学意义(OR:0.367,95%CI:0.160-0.840,P=0.018)。结论STEAP4基因的rs1981529多态性与新疆维吾尔族人的超重及肥胖有关。rs1981529的CC基因型可能是新疆维吾尔族人超重及肥胖的保护因素。Objective To investigate the correlation between gene polymorphisms of prostate transmembrane antigen 4(STEAP4)with overweight and obesity in Xinjiang Uygur population.Methods The study was conducted from a cross-sectional survey of metabolic diseases such as obesity in Hetan region of Xinjiang.general data(gender,age,height,weight,BMI,blood pressure level,etc.)and blood samples were collected for the measurement of liver and kidney function,ions,blood lipid,blood glucose,insulin and other indicators.All cases were divided into different groups according to BMI level.BMI<25kg/m^2was the non-obese group(n=893).BMI≥25kg/m^2 was the overweight and obese group(n=1155).The genotypes of the three polymorphic sites of STEAP4 gene(rs8122,rs34741656,rs1981529)were identified by TaqMan-PCR.Results The genotype(TT,TC,CC)and allele(T,C)of rs1981529 of STEAP4 gene were statistically different between the two groups(P<0.001).The CC genotype frequency was higher in the non-obese group than that in the overweight and obese group(4.4%vs 2.0%).The rs8122 genotypes(AA,AG,GG)and alleles(A,G)were also statistically different between the two groups(P<0.05),while the rs34741656 genotypes(AA,AG,GG)and alleles(A,G)were not statistically different between the two groups(P>0.05).However,multivariate logistic regression analysis showed that only the CC genotype of rs1981529 reduced the risk of overweight and obesity(OR:0.410,95%CI:0.208-0.808,P=0.010).After adjusting for confounding factors,the association was still statistically significant(OR:0.367,95%CI:0.160-0.840,P=0.018).Conclusion The rs1981529 polymorphism of the STEAP4 gene is associated with overweight and obesity in Xinjiang Uygur population.The CC genotype of rs1981529 may be a protective factor for overweight and obesity in Xinjiang Uygur population.

关 键 词：STEAP4 基因多态性 超重 肥胖 流行病学 

分 类 号：R394.5[医药卫生—医学遗传学]