1-[(2-甲氧基-4-乙氧基)-苯基]-3-(3-(4-氧香豆素基)苯基)硫脲的合成  

Synthesis Of 1-[(2-methoxyl-4-oxethyl) Phenyl]-3-[(3-(4-Oxygencoumarin) phenyl) Sulfocarbamide

作　　者：陆阳[1] 陶京朝[2] 周志莲 张志荣[4] Lu Yang;Tao Jingzhao;Zhou Zhilian;Zhang Zhirong(Office of Organic chemistry,Xinyang Agriculture and forestry College,Xinyang 464000 Henan Province,China;Chemistry Department of ZhengZhou University,ZhengZhou Henan 450001,China;New Drug Research and Development Center Henan KeYi Group,Xinyang Henan 464000,China;Henan Province FuBang Pesticides Chemical Engineering Company Manager,Xinyang Henan 464000,China)

机构地区：[1]信阳农林学院有机化学教研室,河南信阳464000 [2]郑州大学化学系,河南郑州450001 [3]河南科易集团新药研究开发中心,河南信阳464000 [4]河南富邦农药化工公司,河南信阳464000

出　　处：《农药科学与管理》2019年第8期31-36,41,共7页Pesticide Science and Administration

摘　　要：制备具有显著抗菌活性的1-[(2-甲氧基-4-乙氧基)苯基]-3-[(3-(4-氧香豆素)苯基]硫脲.以4-氯香豆素为原料,经过醚化、异硫氰酸化和缩合反应合成目标化合物1-[(2-甲氧基-4-乙氧基)-苯基]-3-(3-(4-氧香豆素基)苯基)硫脲.在优化的条件下,反应总收率为61.63%,纯度为99%,其结构经1HNMR分析确认.该化合物具有优良的抗菌活性,该工艺简单经济,条件温和.In order to synthesize 1-[( 2-methoxyl-4-oxethyl) Phenyl]-3-[( 3-( 3-( 4-Oxygencoumarin) phenyl) sulfocarbamide with significant antibacterial activity. The target compound was synthesized from 4-hydroxycoumarin via etherification,isothiocyanate and condensation reactions ’. The structure of synthesized compounds were confirmed by 1 H NMR,IR and GC-MS. The purity was found to be 99%,and the total yield of the three-step process was61. 63%. The compound has excellent antibacterial activity. The process is simple with mild manufacturing condition.

关 键 词：4-氯香豆素 醚化 异硫氰酸化 缩合 

分 类 号：S482.2[农业科学—农药学]