Hedgehog信号通路对肝脏损伤修复作用的研究进展  

Role of Hedgehog Signaling Pathway in Regeneration of Liver Injury

作　　者：金立方[1] 倪坚[1] 闫俊艳 韩继卫[1] 胡保卫[1] Jin Lifang;Ni Jian;Yan Junyan;Han Jiwei;Hu Baowei(School of Life Science,Shaoxing University,Shaoxing 312000,China)

机构地区：[1]绍兴文理学院生命科学学院

出　　处：《中国细胞生物学学报》2019年第8期1615-1621,共7页Chinese Journal of Cell Biology

基　　金：浙江省分析测试和实验动物计划(批准号:2018C37105)资助的课题~~

摘　　要：Hedgehog(Hh)信号通路是胚胎发育的重要形态发生因子,在成体肝脏中活性处于抑制状态,但在多种类型的肝脏损伤中被重新激活。Hh信号通路参与肝脏损伤修复的多个环节,包括肝前体细胞的增殖分化,窦状隙内皮细胞的血管重塑,免疫细胞的炎症反应,以及肝星型细胞的激活和纤维化。该文就Hh信号通路介导的肝脏损伤修复作用进行概述,以期为推动肝脏疾病的治疗提供理论依据。Hedgehog(Hh) signaling pathway, an important morphogenetic factor in embryonic development, is silenced in adult liver and becomes activated in many types of liver injuries. Hh signaling pathway is involved in the repair of liver injury in various aspects, including proliferation and differentiation of hepatic stem/progenitor cells, vascular remodeling of hepatic sinusoidal endothelial cells, inflammation response of immune cells, and activation and fibrosis of hepatic stellate cells. This paper summarizes the researches about role of Hh signaling pathway-mediated liver injury repair, which will provide a theoretical basis for promoting advances in liver disease therapy.

关 键 词：HEDGEHOG信号通路 肝脏 损伤 修复 

分 类 号：R73[医药卫生—肿瘤]