硫酸乙酰肝素与癌症的相关性及其在癌症治疗中的应用策略  

Function and Application of Heparin Sulfate in Cancer

作　　者：吴睿 肖蓉[1] 王继红[1] Wu Rui;Xiao Rong;Wang Jihong(College of Life Sciences,Liaoning Normal University,Dalian 116029,China)

机构地区：[1]辽宁师范大学生命科学学院

出　　处：《中国细胞生物学学报》2019年第8期1665-1670,共6页Chinese Journal of Cell Biology

基　　金：国家高技术研究发展计划(“863”项目)(批准号:2014AA093502);国家自然科学基金(批准号:30770297);大连市科技攻关项目(批准号:2014E12SF067);辽宁省自然科学基金(批准号:20180550829)资助的课题~~

摘　　要：硫酸乙酰肝素以蛋白聚糖形式广泛分布于人体各组织中。硫酸乙酰肝素与蛋白质结合,产生硫酸乙酰肝素蛋白聚糖,参与调节机体各种生理过程,并在癌症发生和发展中起重要作用。该文综述了硫酸乙酰肝素及其蛋白聚糖的结构特点、其与癌症发生发展的相关性以及以硫酸乙酰肝素/硫酸乙酰肝素蛋白聚糖为靶点的癌症治疗策略,以期为相关基础研究及新药开发提供参考。Heparan sulfate is widely distributed in various tissues of the human body in the form of proteoglycans. Heparan sulfate binds to proteins to produce heparan sulfate proteoglycans, to regulate various physiological processes of the body and play an important role in the occurrence and development of cancer. This article reviews the structural characteristics of heparan sulfate and its proteoglycans, their correlation with the development of cancer, and the cancer treatment strategy targeting heparan sulfate/heparan sulfate proteoglycan, in order to provide reference for relevant basic research and new drug development.

关 键 词：硫酸乙酰肝素 硫酸乙酰肝素蛋白聚糖 癌症 

分 类 号：R73[医药卫生—肿瘤]