体质量指数和25羟维生素D3水平与结肠癌相关性研究  

The correlation of BMI and 25 hydroxyvitamin D3 level with colon cancer

作　　者：刘洋[1] 刘俊茹[2] 孟祥彩 李璐璐[2] 赵雅静 王益民[1] LIU Yang;LIU Junru;MENG Xiangcai;LI Lulu;ZHAO Yajing;WANG Yimin(Department of General Surgery,The First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,P.R.China;Department of Endocrinology,The First Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,P.R.China;Department of General Internal Medicine,The Fourth Hospital of Qinhuangdao,Qinhuangdao,Hebei 066000,P.R.China)

机构地区：[1]秦皇岛市第一医院普通外科,河北秦皇岛066000 [2]秦皇岛市第一医院内分泌科,河北秦皇岛066000 [3]秦皇岛市第四医院综合内科,河北秦皇岛066000

出　　处：《中国普外基础与临床杂志》2019年第11期1289-1292,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：河北省卫生厅立项课题（课题编号：20181186）

摘　　要：目的探讨体质量指数(BMI)和25羟维生素D3水平与结肠癌的相关性。方法回顾性选取2017年3–10月期间秦皇岛市第一医院体检中心行结肠镜检查排除肠道疾病者100例作为对照组,普外科或体检中心行结肠镜检查并经病理学检查证实患结肠癌者100例作为结肠癌组,于检查当日晨起空腹测量其身高、体质量及BMI,采空腹静脉血测定25羟维生素D3水平。结果①2组的年龄及25羟维生素D3水平差异无统计学意义(P>0.05),结肠癌组的BMI较对照组明显增高(P<0.05)。②结肠癌组较对照组超重肥胖者比例明显增高,维生素D缺乏者比例明显增高(P<0.05)。③logistic回归分析显示,以结肠癌为因变量,维生素D缺乏者发生结肠癌的比例是维生素D不缺乏者的12.263倍,超重肥胖者发生结肠癌的比例是BMI正常者的2.215倍,差异均具有统计学意义(P<0.05)。结论维生素D缺乏人群与BMI超重肥胖人群的结肠癌发病率明显增高。Objective To explore the correlation of BMI and 25 hydroxyvitamin D3 level with colon cancer.Methods A total of 100 cases who underwent colonoscopy and were excluded from bowel diseases at the physical examination center of the First Hospital of Qinhuangdao from March 2017 to October 2017 were retrospectively selected as the control group.A total of 100 patients who underwent colonoscopy at general surgery or physical examination center and were confirmed to have colon cancer by pathological examination were included in the colon cancer group.The height,weight and body mass index(BMI)were measured in the morning,and the level of 25 hydroxyvitamin D3(25(OH)D3)was determined by fasting blood sampling.Results①There was no statistical significance in age and 25(OH)D3 level between the two groups(P>0.05),and BMI of the colon cancer group was significantly higher than that of the control group(P<0.05).②The proportion of overweight and obesity in the colon cancer group was significantly higher than that in the control group(P<0.05),and the proportion of vitamin D deficiency was significantly higher as well(P<0.05).③Logistic regression analysis showed that the incidence of colon cancer in patients with vitamin D deficiency was 12.263 times higher than that in patients without vitamin D deficiency,and the incidence of colon cancer in patients with overweight and obesity was 2.215 times higher than that in patients with normal BMI,with statistically significant differences(P<0.05).Conclusion The incidence of colon cancer in patients with vitamin D deficiency and those with BMI of overweight or obesity is significantly increased.

关 键 词：结肠癌 25羟维生素D 体质量指数 

分 类 号：R73[医药卫生—肿瘤]