HMGB1在消化系统恶性肿瘤中的研究进展  

Research Progress of HMGB1 in Digestive System Malignant Tumor

作　　者：赵东霞 王丽芳[3] 卢安[1] ZHAO Dong-xia;WANG Li-fang;LU An(Hebei Provincial Center for Disease Prevention and Control,Shijiazhuang 050021,China;Hebei Children’s Hospital,Shijiazhuang 050031,China;Second Hospital of Hebei Medical University,Shijiazhuang 050035,China)

机构地区：[1]河北省疾病预防控制中心,河北石家庄050021 [2]河北省儿童医院,河北石家庄050031 [3]河北医科大学第二医院,河北石家庄050035

出　　处：《肿瘤学杂志》2019年第10期910-915,共6页Journal of Chinese Oncology

摘　　要：消化系统恶性肿瘤在我国恶性肿瘤中较常见,有较高的发病率和死亡率,其早期诊断率低,预后较差。高迁移率族蛋白(HMGB1)是一种非组蛋白染色体结合蛋白,主要存在于细胞核中。近年来研究显示,消化系统肿瘤如肝癌、胃癌、结直肠癌、胰腺癌、食管癌等恶性肿瘤中HMGB1过量表达。当外界环境发生改变时,HMGB1可以主动或被动释放至细胞外,引起下游信号通路的激活,促使肿瘤细胞发生转移、浸润。HMGB1有望成为消化系统恶性肿瘤治疗的新靶点。全文就HMGB1在消化系统恶性肿瘤中的研究进展作一综述。High mobility group protein box 1(HMGB1) is a non-histone chromosome binding protein,mainly located in the nucleus. In recent years,it has been shown that there is an overexpression of HMGB1 in malignant tumors including liver cancer,stomach cancer,colorectal cancer,pancreatic cancer and esophageal cancer. To respond the external environment changes,HMGB1 can be released from the cells actively or passively,activating the downstream signaling pathway,inducing tumor metastasis and invasion. HMGB1 may become a novel target for cancer therapy.This article reviews the progress of HMGB1 in digestive system malignancies and its potential application.

关 键 词：HMGB1 消化系统 恶性肿瘤 

分 类 号：R735[医药卫生—肿瘤]