高迁移率族蛋白2在结直肠癌组织中的表达及临床意义  

Expression of high mobility group box 2 in colorectal cancer tissue and its clinical significance

作　　者：李前[1] 李定明[1] 王卫卫 邱家声 陈泽群 LI Qian;LI Dingming;WANG Weiwei;QIU Jiasheng;CHEN Zequn(Department of Gastrointestinal Surgery,Maoming People’s Hospital,Maoming,Guangdong 525000,China)

机构地区：[1]广东省茂名市人民医院胃肠外科

出　　处：《中国普通外科杂志》2019年第10期1269-1274,共6页China Journal of General Surgery

基　　金：广东省茂名市科技计划资助项目（190408081701511）

摘　　要：目的:探讨结直肠癌癌组织中高迁移率族蛋白2(HMGB2)的表达及其临床意义。方法:收集2012年1月-2014年1月茂名市人民医院胃肠外科收治的82例结直肠癌患者术后组织标本及临床资料,用免疫组化方法检测标本中HMGB2表达,分析HMGB2表达与结直肠癌患者临床病理因素的关系及无瘤生存率和总生存率的关系,并分析影响结直肠癌患者无瘤生存率和总生存率的危险因素。结果:HMGB2高表达者比例为60.9%(50/82),HMGB2低表达者比例为39.1%(32/82)。HMGB2高表达与结直肠癌患者的组织分化程度低、临床分期、T分期、N分期和M分期有关(均P<0.05)。HMGB2高表达患者5年无瘤生存率与总生存率均明显低于HMGB2低表达患者(27.7%vs. 38.7%,P<0.05;32.1%vs. 41.5%,P<0.05)。多因素分析及结果显示,HMGB2与M分期均为结直肠癌患者无瘤生存率(HR=1.771,95%CI=1.146~4.923,P=0.027;HR=3.874,95%CI=1.886~7.824,P=0.002)与总生存率(HR=1.823,95%CI=1.035~3.198,P=0.005;HR=3.865,95%CI=1.770~8.278,P=0.001)的独立危险因素。结论:HMGB2高表达与结直肠癌患者恶性临床病理特征密切相关,且是影响结直肠癌患者预后的独立危险因素。Objective: To investigate the expression of high-mobility group box 2(HMGB2) in colorectal cancer tissue and its clinical significance. Methods: The surgical specimens and clinical data of 82 patients with colorectal cancer treated from January 2012 to January 2014 in the Department of Gastrointestinal Surgery of Maoming People’s Hospital were collected. The HMGB2 expressions in the specimens were detected by immunohistochemical staining. The relations of HMGB2 expression with the clinicopathologic factors and postoperative tumor-free and overall survival rates were analyzed, and the risk factors for postoperative tumor-free and overall survival rates of colorectal cancer patients were also analyzed. Results: The proportion of cases with high HMGB2 expression was 60.9%(50/82) and with low HMGB2 expression was 39.1%(32/82). The high HMGB2 expression was significantly related to histological differentiation, clinical stage, T classification, N classification and M classification of the colorectal cancer patients(all P<0.05). Both 5-year tumor-free survival and overall survival rates in patients with high HMGB2 expression were significantly lower than those in patients with low HMGB2 expression(27.7% vs. 38.7%, P<0.05;32.1% vs. 41.5%, P<0.05). The results of multivariate analyses showed that both HMGB2 expression and M classification were independent risk factors for tumor-free survival(HR=1.771, 95% CI=1.146–4.923, P=0.027;HR=3.874, 95% CI=1.886–7.824, P=0.002) and overall survival rates(HR=1.823, 95% CI=1.035–3.198, P=0.005;HR=3.865, 95% CI=1.770–8.278, P=0.001) in patients with colorectal cancer. Conclusion: High HMGB2 expression is closely associated with malignant clinicopathologic features in patients with colorectal cancer, and also is an independent risk factor for poor prognosis in patients with colorectal cancer.

关 键 词：结直肠肿瘤 高迁移率族蛋白质类 预后 

分 类 号：R735.3[医药卫生—肿瘤]