康柏西普在糖尿病性白内障患者超声乳化术中的应用  

Intravitreal injection of Conbercept during phacoemulsification for diabetic cataract

作　　者：张燕[1] 冯劼[1] 鲁铭[1] 金翼[1] 罗艳[1] 江城[2] ZHANG Yan;FENG Jie;LU Ming;JIN Yi;LUO Yan;JIANG Cheng(From the Department of Ophthalmology,the First Hospital of Wuhan,Wuhan 430022,Hubei Province,China;Department of Panlong General Medicine Center,the First Hospital of Wuhan,Wuhan 430022,Hubei Province,China)

机构地区：[1]武汉市第一医院眼科,湖北省武汉市430022 [2]武汉市第一医院盘龙综合内科,湖北省武汉市430022

出　　处：《眼科新进展》2019年第11期1052-1055,共4页Recent Advances in Ophthalmology

基　　金：武汉市卫生计生委科研基金资助项目(编号:WX17C01、WX16C35、WX15B18)~~

摘　　要：目的探讨白内障超声乳化术中注射康柏西普在糖尿病性白内障治疗中的效果。方法选取2015年7月至2017年5月于我院就诊的糖尿病性白内障患者74例(74眼)为研究对象,按治疗方法不同分为对照组38例(单纯行白内障超声乳化手术)及治疗组36例[白内障超声乳化术中予以玻璃体内注射康柏西普0.05 mL(2.5 mg)]。记录并对比两组患者术前及术后1周、1个月、3个月、6个月的最佳矫正视力(best corrected visual acuity,BCVA)、黄斑中心凹视网膜厚度(foveal retinal thickness,FRT)及术后并发症发生情况。结果治疗组及对照组术后不同时间点BCVA均较术前有不同程度提高(均为P<0.05),术后1周、1个月两组BCVA相比差异均有统计学意义(均为P<0.05)。术后1周、1个月,治疗组FRT分别为(214.694±36.358)μm及(219.417±34.925)μm,均较术前(247.944±50.508)μm降低(均为P<0.05);对照组术后1周及1个月FRT分别为(253.105±46.635)μm及(260.395±68.718)μm,均较术前(245.553±48.653)μm有不同程度增加(均为P<0.05);术后1周、1个月、3个月两组FRT相比差异均有统计学意义(均为P<0.05)。治疗组结膜下出血发生率较对照组高(P<0.05)。结论白内障超声乳化术中予以玻璃体内注射康柏西普治疗糖尿病性白内障短期疗效好。Objective To evaluate the effects of intravitreal injection of Conbercept during phacoemulsification for diabetic cataract.Methods Totally 74 patients(74 eyes)with diabetic cataract diagnosed in our hospital from July 2015 to May 2017 were divided into treatment group[36 patients were treated with intravitreal injection of 0.05 mL(2.5 mg)Conbercept during phacoemulsification]and control group(38 patients were treated with cataract phacoemulsification alone).The best corrected visual acuity(BCVA)and foveal retinal thickness(FRT)before operation,1 week,1 month,3 months and 6 months after operation were recorded and compared,and the complications were recorded.Results The postoperative BCVA at all time points were higher than that before operation in the two groups(all P<0.05).FRT was(214.694±36.358)μm one week after operation and(219.417±34.925)μm one month post-operation in the treatment group,both which were significantly decreased when compared with before operation[(247.944±50.508)μm](all P<0.05).FRT was(253.105±46.635)μm one week after operation and(260.395±68.718)μm one month post-operation in the control group,both which were increased when compared to before operation[(245.553±48.653)μm](all P<0.05).There were significant differences in FRT between the two groups one week,one month,three months after operation(all P<0.05).The incidence rate of subconjunctival hemorrhage was higher in the treatment group than the control group(P>0.05).Conclusion Intravitreal injection of Conbercept during phacoemulsification for diabetic cataract can achieve better short-term outcomes.

关 键 词：康柏西普 白内障超声乳化 糖尿病性白内障 黄斑中心凹视网膜厚度 

分 类 号：R776[医药卫生—眼科]