康柏西普对糖尿病黄斑水肿患者黄斑区视网膜微循环的作用:基于光学相干断层扫描血管成像(OCTA)的评价  

Analysis of the macular retinal microcirculation after intravitreal injection of Conbercept in eyes with diabetic macular edema based on optical coherence tomography angiography

作　　者：沈沛阳 孔祥斌 周立军 苏鹏 黄玉娟 周怀胜 陆晓和[1] SHEN Pei-Yang;KONG Xiang-Bin;ZHOU Li-Jun;SU Peng;HUANG Yu-Juan;ZHOU Huai-Sheng;LU Xiao-He(From the Department of Ophthalmology,Zhujiang Hospital of Southern Medical University,Guangzhou 510282,Guangdong Province,China;Department of Ophthalmology,the Second People’s Hospital of Foshan(Affiliated Foshan Hospital of Southern Medical University),Foshan 528000,Guangdong Province,China)

机构地区：[1]南方医科大学珠江医院眼科,广东省广州市510282 [2]佛山市第二人民医院(南方医科大学附属佛山医院),广东省佛山市528000

出　　处：《眼科新进展》2019年第11期1056-1059,共4页Recent Advances in Ophthalmology

基　　金：2019广东省医学科学技术研究基金(编号:B2019079);广东省佛山市博士后专项基金(编号:214901);2017白求恩·默克糖尿病研究基金临床研究项目~~

摘　　要：目的应用光学相干断层扫描血管成像(OCTA)评价康柏西普对糖尿病黄斑水肿患者黄斑区视网膜微循环的影响。方法回顾性分析17例(20眼)糖尿病黄斑水肿患者资料,所有患者均行玻璃体内注射康柏西普治疗。分析比较术前和术后1个月患者最佳矫正视力、视网膜中央厚度和OCTA测得的视网膜各参数。结果所有患者抗VEGF治疗后随访1个月,效果良好;最佳矫正视力(logMAR)从术前的0.66±0.23提高到0.50±0.26;视网膜中央厚度从术前的(497.2±71.6)μm降至(341.3±54.2)μm,差异均有统计学意义(均为P<0.05)。OCTA测量的无血管区面积和各毛细血管层的黄斑区血管密度等参数在抗VEGF治疗前后差异均无统计学意义(均为P>0.05)。结论玻璃体内注射康柏西普能够有效减轻黄斑水肿、提高视力,且不会加剧黄斑区无灌注程度,不会加重黄斑区微循环障碍。Objective To observe the clinical therapeutic efficacy of a single intravitreal injection of Conbercept for diabetic macular edema,and to evaluate the macular perfusion status using optical coherence tomography angiography(OCTA).Methods A retrospective study was conducted in 17 patients(20 eyes)and the clinical data were reviewed and analyzed.All patients received the intravitreal injection of Conbercept,and underwent best-corrected visual acuity(BCVA),central retinal thickness and OCTA measurements before and one month after intravitreal injection.Results The study evaluated 20 eyes of 17 patients with diabetic macular edema[mean(67.2±11.6)years old].At 1 month after injection,the logarithm of minimum angle of resolution(logMAR)BCVA significantly improved from(0.66±0.23)logMAR to(0.50±0.26)logMAR(P<0.05),and the average central retinal thickness decreased significantly from(497.2±71.6)μm to(341.3±54.2)μm(P<0.05).No significant difference was found with respect to the foveal avascular zone area and vessel density in the fovea and parafovea(all P>0.05).Conclusion This study demonstrated that intravitreal injection of Conbercept can alleviate the diabetic macular edema and restore the visual acuity.The foveal avascular zone area and vessel density remained stable after a single intravitreal anti-VEGF injection.

关 键 词：光学相干断层扫描血管成像 康柏西普 糖尿病黄斑水肿 

分 类 号：R776.1[医药卫生—眼科]