基于肠道菌群调节的中医药防治非酒精性脂肪肝的研究进展  

Advances in Research on Prevention and Treatment of Nonalcoholic Fatty Liver Disease Based on Gut Microbiota Regulation

作　　者：李宝龙[1] 王娇娇 段婷婷 黄家鹏 高彤 李松滨[1] 孙劲晖[2] LI Baolong;WANG Jiaojiao;DUAN Tingting;HUANG Jiapeng;GAO Tong;LI Songbin;SUN Jinhui(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Spleen and Stomach Disease,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]北京中医药大学东直门医院脾胃科,北京100700

出　　处：《医学综述》2019年第21期4281-4285,共5页Medical Recapitulate

基　　金：国家自然科学基金面上项目(81573135,81573969);黑龙江省教育厅科学技术研究项目(12541763)

摘　　要：非酒精性脂肪肝(NAFLD)是一种代谢综合征在肝脏的表现,其发病机制复杂。近年来相关的研究发现肠道菌群参与NAFLD的疾病过程。肠道菌群紊乱和肠道通透性增加导致肠道内细菌和内毒素通过门静脉系统进入肝脏,加剧了NAFLD的发展。目前,传统中医药治疗NAFLD的疗效受到认可。中药在胃肠道中与肠道菌群相互作用,通过影响菌群的生理功能、免疫调节、菌群代谢等对肠道菌群进行调节,使肠道微生态趋于平衡,减少细菌易位和内毒素的增加,从而减轻NAFLD的程度,这可能是中药防治NAFLD新的作用机制。Non-alcoholic fatty liver disease( NAFLD) is a manifestation of metabolic syndrome in the liver,and its pathogenesis is complex. In recent years,related research has found that gut microbiota participates in the occurrence and progression of NAFLD. When the disorder of gut microbiota and the intestinal permeability increase,the intestinal bacteria and endotoxin enter the liver through the portal system,which will aggravate the occurrence and development of NAFLD. At present,the effective treatment of traditional Chinese medicine for the NAFLD is recognized. The Chinese medicine interacts with the gut microbiota in the gastrointestinal tract and regulates the gut microbiota by affecting the physiological functions,immune regulation,and the microbiota metabolism,which makes the intestinal micro-ecology tend to balance and reduce the increase of bacterial translocation and endotoxin,and reduce the NAFLD severity. It may be a new mechanism of Chinese medicine for the prevention and treatment of NAFLD.

关 键 词：肠道菌群 肠-肝轴 中药 非酒精性脂肪肝 内毒素 

分 类 号：R737[医药卫生—肿瘤]