正畸微型种植体支抗对错颌畸形患者支抗种植体周围炎症及牙周微环境的影响  

Effects of mini-implant anchorage in orthodontic treatment on periodontal inflammation and periodontal microenvironment of anchorage implants

作　　者：苗朝旭[1] 王竞博 房博 MIAO Zhao-xu;WANG Jing-bo;FANG Bo(Department of Stomatology,Xi'an Central Hospital,Xi'an 710003,Shanghai,CHINA)

机构地区：[1]西安市中心医院口腔科

出　　处：《海南医学》2019年第21期2782-2784,共3页Hainan Medical Journal

摘　　要：目的探讨正畸微型种植体支抗对错颌畸形患者支抗种植体周围炎症及牙周微环境的影响。方法选择2017年8月至2018年8月西安市中心医院口腔科收治的120例错颌畸形患者进行研究。按照随机数表法将患者均分为对照组和观察组,每组60例。对照组采取常规口外弓治疗措施,观察组采取微型种植体治疗,治疗3个月后,比较两组患者的口腔结构、炎症反应及牙周微环境情况。结果观察组患者的上中切牙凸距差和中切牙倾角差分别为(4.24±1.26)mm、(26.42±5.34)mm,明显高于对照组的(2.45±1.21)mm、(12.44±3.65)mm,但磨牙移位为(3.21±0.24)mm,明显低于对照组的(6.32±0.31)mm,差异均有统计学意义(P<0.05);治疗3个月后,观察组患者的白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)水平分别为(62.23±6.26)μg/g、(128.45±12.27)μg/g、(182.75±7.43)μg/g,均明显低于对照组的(82.45±8.13)μg/g、(162.24±14.21)μg/g、(212.25±10.34)μg/g,差异均有统计学意义(P<0.05);观察组患者的基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)表达水平分别为(2.23±0.13)μg/g、(2.31±0.18)μg/g,均明显低于对照组的(3.67±0.42)μg/g、(3.89±0.65)μg/g,差异均有统计学意义(P<0.05)。结论正畸微型支抗种植体治疗能够有效降低支抗种植体周围炎症发生,改善牙周微环境。Objective To investigate the effects of mini-implant anchorage in orthodontic treatment on periodontal inflammation and periodontal microenvironment of anchorage implants in patients with malocclusion.Methods A total of 120 patients with malocclusion,who admitted to Department of Stomatology of Xi’an Central Hospital from August 2017 to August 2018,were selected and divided into the control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with conventional external arch of the mouth,while the observation group was treated with micro-implant.After 3 months of treatment,the oral structure,inflammatory reaction and peridental microenvironment of the two groups were compared.Results In the observation group,the difference in the protrusion distance and inclination angle of the upper central incisors were(4.24±1.26)mm and(26.42±5.34)mm,respectively,which were significantly higher than corresponding(2.45±1.21)mm and(12.44±3.65)mm of the control group;but the molar displacement was(3.21±0.24)mm,which was significantly lower than(6.32±0.31)mm of the control group(all P<0.05).After 3 months of treatment,the levels of interleukin-6(IL-6),interleukin-1 beta(IL-1β),and tumor necrosis factor(TNF-α)in the observation group were(62.23±6.26)μg/g,(128.45±12.27)μg/g,and(182.75±7.43)μg/g,respectively,which were significantly lower than corresponding(82.45±8.13)μg/g,(162.24±14.21)μg/g,and(212.25±10.34)μg/g in the control group(all P<0.05).The expression levels of MMP-2 and MMP-9 in the observation group were(2.23±0.13)μg/g and(2.31±0.18)μg/g,respectively,which were significantly lower than corresponding(3.67±0.42)μg/g and(3.89±0.65)μg/g in the control group(all P<0.05).Conclusion Orthodontic mini-implants therapy can effectively reduce the inflammation around anchorage implants and improve the peridental microenvironment.

关 键 词：错颌畸形 正畸治疗 支抗种植体 炎症微环境 牙周组织 

分 类 号：R783.5[医药卫生—口腔医学]