SOX11在套细胞淋巴瘤组织中的表达及其意义  

SOX11 expression and significance in Mantle cell lymphoma

作　　者：温永琴[1] 何建芳[1] WEN Yong-qin;HE Jian-fang(Department of Pathology,Dongguan People’s Hospital,Dongguan 523000,China)

机构地区：[1]广东省东莞市人民医院病理科

出　　处：《广东医科大学学报》2019年第5期506-509,共4页Journal of Guangdong Medical University

基　　金：东莞市社会科技发展项目(No.201650715001384)

摘　　要：目的了解套细胞淋巴瘤(MCL)组织中SOX11表达及意义。方法采用免疫组化方法检测146例非霍奇金B细胞淋巴瘤组织中SOX11表达。结果20例MCL、25例Burkitt淋巴瘤、46例弥漫大B细胞淋巴瘤、36例淋巴结及结外边缘区淋巴瘤、19例小淋巴细胞淋巴瘤组织中SOX11阳性表达率分别为100.0%、16.0%、4.3%、2.8%、0%;MCL中SOX11表达率明显高于其它类型B细胞淋巴瘤(P<0.01)。结论SOX11高表达是诊断MCL的重要免疫组化指标。Objective To study SOX11 expression and significance in mantle cell lymphoma(MCL).Methods SOX11 expression was detected by immunohistochemistry in 146 non-Hodgkin’s B cell lymphomas.Results Positive expression rates of SOX11 were 100.0% in 20 MCLs,16.0% in 25 Burkitt lymphomas,4.3% in 46 diffuse large B cell lymphomas,2.8%in 36 marginal zone lymphomas,and 0% in 19 small lymphocytic lymphomas.SOX11 expression was significantly higher in MCL than in other B cell lymphomas(P<0.01).Conclusion SOX11 overexpression is an important immunohistochemical marker for MCL.

关 键 词：B细胞淋巴瘤 套细胞淋巴瘤 SOX11 

分 类 号：R733.4[医药卫生—肿瘤]