血清C3a联合TCT、HC2-HPV检测对宫颈癌早期诊断的价值  

Value of serum C3a combined with TCT and HC2-HPV detection in the early diagnosis of cervical cancer

作　　者：杨佩娴 余鑫 吴绮霞[1] YANG Pei-xian;YU Xin;WU Qi-xia(Department of Gynecology,the Central Hospital of Kaiping,Jiangmen 529300,China)

机构地区：[1]广东省开平市中心医院妇科

出　　处：《广东医科大学学报》2019年第5期529-531,共3页Journal of Guangdong Medical University

基　　金：江门市卫生计生局科学技术研究项目(No.19A095)

摘　　要：目的研究血清C3a联合新柏氏液基细胞学检测(TCT)、高危型人乳头瘤病毒2型(HC2-HPV)检测对宫颈癌早期诊断的价值。方法选取妇科就诊且疑似宫颈癌患者作为研究对象,根据病理诊断结果分为良性细胞改变组(BCC组)、不典型增生轻度组(CIN-Ⅰ组)、不典型增生中度组(CIN-Ⅱ组)、不典型增生重度组(CIN-Ⅲ组)、宫颈癌组(SCC组),并纳入子宫颈炎性病变患者作为阳性对照组(Pos-Ctrl组),以及宫颈无病变的健康女性作为阴性对照组(Neg-Ctrl组)。比较各组女性外周血C3a水平,并计算SCC组患者的C3a诊断切割值,进一步比较血清C3a联合或不联合TCT、HC2-HPV用于诊断宫颈癌时的敏感性、特异性、阳性预测值等。结果SCC组患者的血清C3a水平显著高于其他各组(P<0.01)。将C3a的P75值为49.92作为诊断切割值。血清C3a、TCT和HC2-HPV联合检测SCC的敏感性、特异性、阳性预测值、阴性预测值均高于TCT、HC2-HPV单独检测或TCT和HC2-HPV联合检测。结论C3a联合TCT、HC2-HPV检测对宫颈癌的早期诊断有更高的敏感性和特异性,提高了宫颈癌筛查的准确性。Objective To study the clinical value of serum C3a combined with TCT and HC2-HPV in the early diagnosis of cervical cancer.Methods The patients sought medical advice and suspected of cervical cancer were selected.The patients were divided into the benign cell change group(BCC Group),mild atypical hyperplasia group(CIN-Ⅰ group),intermediate atypical hyperplasia group(CIN-Ⅱ group),severe atypical hyperplasia group(CIN-Ⅲ group)and cervical cancer group(SCC Group).The patients with cervical inflammation were included as positive control group(Pos-Ctrl Group)while the patients with no cervical lesion were included as negative control group(Neg-Ctrl Group).The C3a level in peripheral blood of women in each group was compared and the diagnostic cut-off value of C3a in SCC Group was calculated.The sensitivity,specificity and positive predictive value of serum C3a combined or not combined with TCT and HC2-HPV in the diagnosis of cervical cancer were further compared.Results The serum C3a level of the SCC Group was significantly higher than that of other groups,and the difference was statistically significant(P<0.05).49.92,the P75 value of C3a,was taken as the diagnostic cutoff value.The sensitivity,specificity,positive predictive value and negative predictive value of serum C3a combined TCT and HC2-HPV detection were significantly higher than those of separation detection of TCT and HC2-HPV or combined TCT and HC2-HPV detection.Conclusion C3a combined with TCT and HC2-HPV detection has higher sensitivity and specificity in the early diagnosis of cervical cancer,which improves the accuracy of cervical cancer screening.

关 键 词：宫颈癌 C3A TCT HC2-HPV 早期诊断 

分 类 号：R737[医药卫生—肿瘤]