载125I粒子链胃肠管长期留置治疗晚期食管癌的效果  

Efficacy of long-term indwelling of gastrointestinal tube with 125I seed in treatment of advanced esophageal cancer

作　　者：王旭杰 王梓函 程楷[1] 李春梅[3] 朱宗平[4] 丁月云[4] WANG Xujie;WANG Zihan;CHENG Kai;LI Chunmei;ZHU Zongping;DING Yueyun(Department of Interventional Radiology,Qingdao Municipal Hospital,Qingdao266000,China;Department of Ultrasound,Qingdao Municipal Hospital,Qingdao266000,China;Department of Radiology,Qingdao Municipal Hospital,Qingdao266000,China;Department of Nuclear Medicine,Qingdao Municipal Hospital,Qingdao266000,China)

机构地区：[1]青岛市市立医院微创介入治疗中心,山东青岛266000 [2]青岛市市立医院超声科,山东青岛266000 [3]青岛市市立医院放射科,山东青岛266000 [4]青岛市市立医院核医学科,山东青岛266000

出　　处：《中国介入影像与治疗学》2019年第11期645-648,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金青年科学基金项目(81601524)

摘　　要：目的探讨载^125I粒子链胃肠管长期留置治疗晚期食管癌患者的效果。方法对11例晚期食管癌患者给予载^125I粒子链胃肠管长期留置,记录技术成功率,术前及术后2个月进食困难分级、食管病变最大层面的管壁厚度,统计治疗有效率及胸痛、出血等不良反应。结果11例患者均成功置入载^125I粒子链胃肠管,技术成功率为100%(11/11)。术后2个月时,11例患者进食困难均获不同程度改善,进食困难Stooler分级由术前的(3.55±0.52)级,降至(1.09±0.70)级;食管病变最大层面的管壁厚度由术前(21.65±4.50)mm,降至(11.38±4.20)mm,管壁厚度收缩率(48.89±10.50)%;治疗有效率为90.91%(10/11);均未见食管瘘、出血等严重并发症。回收的鼻肠管均未出现断裂、粒子丢失及移位。结论载^125I粒子链胃肠管长期留置治疗晚期食管癌的效果较好。Objective To observe the efficacy of long-term indwelling of gastrointestinal tube with ^125I seeds chains in patients with advanced esophageal cancer.Methods Long-term indwelling of gastrointestinal tube with ^125I seeds chains were performed on 11 patients with advanced esophageal cancer.The success rate of operation was recorded.Eating difficulty classification(Stooler grade),wall thickness of esophageal lesions in the largest layer,effective rate and adverse reactions such as chest pain,bleeding were calculated before and 2 months after operation.Results The success rate of operation was 100%(11/11).Two months after operation,the 11 patients’eating difficulty improved at different degree,the Stooler grade of dysphagia decreased from preoperative(3.55±0.52)grade to(1.09±0.70)grade.The maximum wall thickness of esophageal lesions decreased from preoperative(21.65±4.50)mm to(11.38±4.20)mm after operation,and the wall thickness contraction rate was(48.89±10.50)%.The effective rate was 90.91%(10/11),without severe complications such as esophageal fistula and hemorrhage.No rupture,loss or displacement of ^125I seeds was found on the recovered gastrointestinal tube.Conclusion Long-term indwelling of gastrointestinal tube with ^125I seeds chains is effective in the treatment of advanced esophageal cancer.

关 键 词：食管肿瘤 碘同位素 介入治疗 

分 类 号：R735.1[医药卫生—肿瘤] R815[医药卫生—临床医学]