低密度脂蛋白受体相关蛋白1基因多态性与中国人阿尔茨海默病发病风险的meta分析  

Low-density lipoprotein receptor-related protein 1 gene polymorphism and risk of onset of Alzheimer’s disease in Chinese population:A meta-analysis

作　　者：刘东明 易芳[1] 许宏伟[1] 周琳[1] 周亚芳[1] LIU Dong-Ming;YI Fang;XU Hong-Wei;ZHOU Lin;ZHOU Ya-Fang(Department of Geratology,Xiangya Hospital,Central South University/National Clinical Research Center for Geriatric Disorders(Xiangya),Changsha,410008,China)

机构地区：[1]中南大学湘雅医院老年神经内科/国家老年疾病临床医学研究中心(湘雅)

出　　处：《国际神经病学神经外科学杂志》2019年第5期509-514,共6页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨低密度脂蛋白受体相关蛋白1(LRP-1)基因C766T位点多态与中国人阿尔茨海默病(AD)发病风险的关系.方法应用LRP-1、low density lipoprotein receptor related protein 1 gene、阿尔茨海默病等关键词,检索中国期刊全文数据库(CJFD)、Medline、Cochrane图书馆与中国生物医学文献数据库(CBMdisc)4个数据库,对1997年1月至2019年6月公开发表的关于中国人阿尔茨海默病LRP-1基因多态性的病例对照研究进行meta分析.结果共纳入16项病例对照研究.综合数据分析,CC基因型及C等位基因与中国人AD发病相关,均P<0.05,差异有统计学意义;中国人携带CC基因型发生AD的风险是携带CT/TT基因型的1.477倍,携带C等位基因发生AD的风险是携带T等位基因的1.669倍.CC基因型及C等位基因与汉族人AD发病亦相关,均P<0.05,差异有统计学意义;汉族人携带CC基因型发生AD的风险是携带CT/TT基因型的1.711倍,携带C等位基因发生AD的风险是携带T等位基因的2.005倍.结论LRP-1基因C766T位点多态性与中国人,尤其是汉族人AD发病风险相关,携带CC基因型和C等位基因的个体有更大风险发生AD.Objective To investigate the relationship between the C766T polymorphism in the low-density lipoprotein receptor-related protein 1(LRP-1)gene and the risk of onset of Alzheimer's disease(AD)in China.Methods We searched Chinese Journal Full-Text Database,Medline,Cochrane Library,and China Biology Medicine disc for case-control studies about the relationship between the LRP-1 polymorphisms and Alzheimer's disease in Chinese population from January 1997 to June 2019,using keywords such as"LRP-1","low-density lipoprotein receptor-related protein 1 gene",and"Alzheimer's disease".A meta-analysis was performed for the included studies.Results Sixteen eligible case-control studies were included.According to comprehensive data analysis,there was a significant association of AD onset with CC genotype and C allele in Chinese population(P<0.05);Han Chinese population yielded the same result.CC genotype carriers had a 1.477-fold and 1.711-fold risk of developing AD relative to CT/TT genotype carriers in Chinese and Han Chinese populations,respectively.C allele carriers had a 1.669-fold and 2.005-fold risk of developing AD relative to T allele carriers in Chinese and Han Chinese populations,respectively.Conclusions The C766T polymorphism in the LRP-1 gene is associated with the risk of onset of AD in Chinese population,especially Han Chinese population,and CC genotype or C allele carriers have a higher risk.

关 键 词：阿尔茨海默病 低密度脂蛋白受体相关蛋白1基因 多态性 META分析 

分 类 号：R73[医药卫生—肿瘤]