鼻咽癌患者放疗引发小世界网络变化:三维结构MRI数据研究  

Radiation-induced changes in small world network in patients with nasopharyngeal carcinoma:a three-dimensional structure MRI imaging study

作　　者：辛欣 程川东 李厨荣[1] 黎杰[1] 王培[1] 田银[2] 尹刚[1] 郎锦义[1] Xin Xin;Cheng Chuandong;Li Churong;Li Jie;Wang Pei;Tian Yin;Yin Gang;Lang Jinyi(Department of Radiation Oncology,Sichuan Cancer Hospital/Radiation Oncology Key Laboratory of Sichuan Province,Chengdu 610041,China;Chongqing University of Posts and Telecommunications,Chongqing 404100,China)

机构地区：[1]四川省肿瘤医院放疗中心/放射肿瘤学四川省重点实验室,成都610041 [2]重庆邮电大学,404100

出　　处：《中华放射肿瘤学杂志》2019年第11期811-816,共6页Chinese Journal of Radiation Oncology

基　　金：四川省卫计委项目(16PJ512);四川省医学会项目(S17068);四川省科技厅重大专项计划(2017SZ0004);四川省科技厅项目(2019YFG0185);四川省科技计划项目(2019YJ0581)。

摘　　要：目的探索鼻咽癌患者放疗后大脑结构网络的变化。方法利用三维结构MRI数据研究103个鼻咽癌患者放疗前后的结构网络。构建患者的结构网络,并利用图论分析放疗诱发的小世界网络拓扑结构的变化。结果放疗前和放疗后患者均具有小世界属性。相对于放疗前组,放疗后组具有较低的全局和局部效率、更长的最短路径长度、更低的聚类系数。此外,放疗后组的hub区域与放疗前明显不同,主要位于左侧眶部额中回、右侧岛盖部额下回、右侧海马旁回、右侧舌回、双侧缘上回、左侧颞上回、右侧颞中回颞极。结论推测放疗导致网络拓扑和信息传递效率变高,为探索放疗诱发大脑变化、诊断放疗诱发损伤和评估放疗效果提供了一个新视角。Objective To investigate the radiotherapy(RT)-induced changes in the brain structural network in patients with nasopharyngeal carcinoma(NPC).Methods Three-dimensional structural magnetic resonance data(3D-T1W)was adopted to investigate the structural network in 103 patients with NPC before and after receiving RT.The structural networks were then reconstructed using 3D-T1W.The radiation-induced changes in topology properties of small world network were analyzed by using graph theoretical analysis.Results Patients showed small world properties before and after RT.Compared with the pre-RT group,the global and local efficiency were lower,the shortest path length was longer and the clustering coefficient was less in the post-RT group.In addition,the hub regions in the post-RT group were significantly different from those in the pre-RT group,mainly located in the left rolandic operculum,right inferior frontal gyrus,right parahippocampal gyrus,right lingual gyrus,bilateral supramarginal gyrus,left superior temporal gyrus and temporal pole of the right middle temporal gyrus.Conclusion It is speculated that RT leads to high efficiency of network topology and information transmission,which provides a novel perspective for exploring the RT-induced brain changes,diagnosis of RT-induced injury and evaluation of RT efficacy.

关 键 词：鼻咽肿瘤/放射疗法 基于体素的形态学分析 脑灰质 小世界属性 

分 类 号：R73[医药卫生—肿瘤]