早期食管癌内镜下切除术后辅助治疗决策进展  

Progress in adjuvant therapy decision-making after endoscopic resection of early esophageal cancer

作　　者：冯玲玲 门玉 惠周光 Feng Lingling;Men Yu;Hui Zhouguang(Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Shenzhen 518116,China;Department of VIP Medical Servicess,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC),Beijing 100021,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院放疗科,518116 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院特需医疗部,100021

出　　处：《中华放射肿瘤学杂志》2019年第11期867-871,共5页Chinese Journal of Radiation Oncology

基　　金：国家重点研发计划项目(2017YFC1311000);国家自然科学基金项目(81372418);中国医学科学院医学与健康科技创新工程项目(重大协同创新项目2016-I2M-1-011)。

摘　　要：早期食管癌的主要治疗模式包括内镜治疗和外科手术治疗。与根治性手术相比,内镜切除具有创伤小、恢复快、费用低、并发症少、可保留食管正常解剖结构和生理功能以及术后生活质量高的优势。对于淋巴结转移风险高的患者单纯内镜下切除术会导致治疗不充分,应给予辅助治疗。目前临床常用的辅助治疗方式包括辅助放化疗和联合手术两种模式。内镜切除与哪种辅助治疗联合能最大程度让患者获益是目前临床研究的热点。本文就高危患者内镜切除联合辅助治疗的研究现状、进展和存在的问题进行深入阐述。Both endoscopic resection and surgery are the common treatment modes for early esophageal cancer.Compared with radical surgery,endoscopic resection has the advantages of less trauma,quicker recovery,lower cost,less complications,the preservation of the normal anatomy,the physiological function of the esophagus,and higher postoperative quality of life.For patients with a high risk of lymph node metastasis,endoscopic resection alone can lead to inadequate treatment,which need adjuvant therapies.Currently,the common adjuvant therapies consist of adjuvant radiochemotherapy and adjuvant radiochemotherapy combined with surgery.How to combine endoscopic resection with adjuvant therapy to bring maximal benefits to patients has become the hot topic in the field of clinical researches.In this article,the current research status,progress and challenges in the combination of endoscopic resection and adjuvant therapy for the treatment of high-risk patients were reviewed.

关 键 词：食管肿瘤/内镜治疗 食管肿瘤/外科学 食管肿瘤/放化疗 进展 

分 类 号：R73[医药卫生—肿瘤]