粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习  

Fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation

作　　者：王倩 符粤文 王勇奇 艾昊 袁芳芳 魏旭东 宋永平 Wang Qian;Fu Yuewen;Wang Yongqi;Ai Hao;Yuan Fangfang;Wei Xudong;Song Yongping(Department of Hematology,The Anti-Cancer Hospital Affiliated with Zhengzhou University,Zhengzhou 450008,China)

机构地区：[1]郑州大学附属肿瘤医院血液科,450008

出　　处：《中华血液学杂志》2019年第10期853-855,共3页Chinese Journal of Hematology

基　　金：河南省医学科技攻关计划(201502026)。

摘　　要：目的探讨粪菌移植治疗异基因造血干细胞移植后难治性腹泻的有效性及安全性.方法纳入4例行异基因造血干细胞移植后并发难治性腹泻急性白血病患者,其中难治性肠道感染l例、肠道急性移植物抗宿主病3例.每例患者经鼻空肠管注入粪菌1~2次,每次3.4~6.0 U,观察粪菌移植后的疗效与不良反应.结果4例患者中3例达到完全缓解(CR),l例稳定(SD).不良反应包括低热、腹痛、腹泻,均为Ⅰ级.结论粪菌移植治疗异基因造血干细胞移植后难治性腹泻可取得较好疗效,不良反应可耐受.Objective To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods Four acute leukemia patients suffered from refractory diarrhea after allo-HSCT.One of them was refractory intestinal infection,the others were intestinal graft versus host disease.One or two doses of fecal microbiota,3.4-6.0 U for one dose,were infused via nasal-jejunal tube.The curative effect and side effects were reviewed.Results Three cases achieved complete remission while 1 was stable disease.The side effects included fever,abdominal pain and diarrhea,which all were I grade.Conclusion Fecal microbiota transplantation was effective and safe for refractory diarrhea after allo-HSCT.

关 键 词：造血干细胞移植 腹泻 移植物抗宿主病 粪菌移植 

分 类 号：R73[医药卫生—肿瘤]