肥胖型牙周炎患者牙周基础治疗后龈沟液中瘦素、网膜素-1和肿瘤坏死因子-α的水平  

The levels of leptin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese periodontitis patients after periodontal therapy

作　　者：乌玉红 张沁 吕威 张红梅 白璐 WU Yu-hong;ZHANG Qin;LV Wei;ZHANG Hong-mei;BAI Lu(The Periodontal Department of the Affilated Hospital of Chifeng University,Chifeng 024000,China)

机构地区：[1]赤峰学院附属医院牙周科

出　　处：《北京口腔医学》2019年第5期270-274,共5页Beijing Journal of Stomatology

基　　金：内蒙古自治区卫生计生科研项目(201702161)

摘　　要：目的分析肥胖型和非肥胖型牙周炎患者行牙周基础治疗后、龈沟液中瘦素(Leptin)、网膜素-1(Omentin-1)及肿瘤坏死因子-α(TNF-α)的水平。方法筛选符合研究条件的共116人,依据其牙周状况和体质指数测量结果分为4组,分别为牙周健康组(CTRL),慢性牙周炎组(CP),肥胖型牙周健康组(O-CTRL)和肥胖型慢性牙周炎组(O-CP)。牙周炎患者接受牙周基础治疗,治疗前及治疗后4周记录牙周临床指数、并采集样本位点的龈沟液检测瘦素、网膜素-1及肿瘤坏死因子-α的水平,数据行统计学分析。结果O-CP组的Leptin水平显著升高。牙周治疗后CP组的Leptin水平明显降低(P<0.05)。此外,CP组在牙周治疗前后的Leptin水平存在着显著的差异(P<0.05)。与O-CTRL组相比,CP组和O-CP组的网膜素-1水平更低。O-CP组的TNF-α水平显著升高。牙周治疗后,其TNF-α水平也有显著降低(P<0.05)。结论龈沟液中的Leptin及Omentin-1水平可能作为一种可靠的生物标记物,评估牙周病的预后及疗效。Objective To determine the levels of leptin,omentin-1 and tumor necrosis factor-alpha(TNF-α)in the gingival crevicular fluid(GCF)of obese and non-obese periodontitis patients following nonsurgical periodontal therapy.Methods A total of 116 patients were included in the study.They were divided into four groups,periodontal healthy group,chronic periodontitis(CP)group,periodontal healthy with obesity group,and CP with obesity group(O-CP).Nonsurgical periodontal treatment was administered to periodontitis patients.Before treatment and at four weeks after treatment,the clinical periodontal parameters were examined and GCF samples were analyzed.Results the level of leptin in O-CP increased significantly.After periodontal treatment,the level of leptin in CP decreased significantly(P<0.05).There was a significant difference in the level of leptin before and after periodontal treatment in CP(P<0.05).Omentin-1 level was lower in CP group and O-CP group than that in O-CTRL.The level of TNF-αincreased significantly in O-CP group.After treatment,the level of TNF-αalso significantly decreased(P<0.05).Conclusion The levels of leptin and omentin-1 of GCF may serve as biological makers for diagnosis and prognosis of periodontal disease and therapeutic outcome.

关 键 词：肥胖 牙周炎 龈沟液 瘦素 网膜素-1 肿瘤坏死因子-Α 

分 类 号：R781.42[医药卫生—口腔医学]